背景:加拿大多发性硬化症成人体力活动指南(PAGs)于2013年发布,但尚未得到验证。我们的目的是测试PAG在改善健康方面的有效性,移动性,疲劳症状,和生活质量(QOL)在一个大队列的成人多发性硬化症(MS)。
方法:作为正在进行的检查PAG实施情况的随机对照试验的一部分,参与者被随机分为直接转诊组(医师转诊后接受PAG的锻炼计划;n=42)或对照组(提供PAG的打印本;n=37).通过每周的身体活动日志评估身体活动行为。Fitness,移动性,疲劳症状,在基线和16周后评估QOL。根据至少75%的时间实现每周锻炼建议,参与者被归类为PAG信徒(n=30)或非信徒(n=49)。
结果:转诊组对PAG的依从性是对照组的两倍。坚持者在峰值耗氧量(29%)方面经历了显著更大的改善,强度(7%-18%),流动性(16%),疲劳症状(-36%),和生活质量(17%-22%)与非股东相比(P<0.05)。
结论:在16周的PAG之后至少12周可以改善健康,移动性,疲劳症状,和QOL,确认其对改善MS患者健康的有效性。
BACKGROUND: The Canadian Physical Activity
Guidelines for Adults with Multiple Sclerosis (PAGs) were released in 2013 but have yet to be validated. We aimed to test the effectiveness of the PAGs in improving fitness, mobility, fatigue symptoms, and quality of life (QOL) in a large cohort of adults with multiple sclerosis (MS).
METHODS: As part of an ongoing randomized controlled trial examining implementation of the PAGs, participants were randomized to either a direct referral group (physician referral to an exercise program following the PAGs; n = 42) or a control group (provided a print copy of the PAGs; n = 37). Physical activity behavior was assessed through weekly physical activity logs. Fitness, mobility, fatigue symptoms, and QOL were assessed at baseline and after 16 weeks. Participants were categorized as either PAG adherers (n = 30) or nonadherers (n = 49) to the PAGs based on achieving the weekly exercise recommendations at least 75% of the time.
RESULTS: Adherence to the PAGs was twice as high in the referral group compared with the control group. Adherers experienced significantly greater improvements in peak oxygen consumption (29%), strength (7%-18%), mobility (16%), fatigue symptoms (-36%), and QOL (17%-22%) compared with nonadherers (P < .05).
CONCLUSIONS: Following the PAGs for at least 12 of 16 weeks results in improvements in fitness, mobility, fatigue symptoms, and QOL, confirming their effectiveness for improving health in people with MS.