UNASSIGNED: For patients who need laparoscopic radical gastrectomy, lymph node dissection (LND) and optimization of surgical procedures are particularly important. This study introduces the \"quadrant-sandwich\" method in clockwise modular D2 LND and evaluates the advantages and safety of this method.
UNASSIGNED: The clinical data of 108 laparoscopic total gastrectomy patients admitted to the Affiliated Cancer Hospital of Zhengzhou University from January 2019 to January 2022 were retrospectively analyzed. Based on the different LND processes, 55 patients were allocated to the observation group, which underwent clockwise modular LND using the \"quadrant-sandwich method\", and 53 patients were allocated to the control group, which underwent traditional LND. The effectiveness and safety of the approach in terms of operation time, blood loss, lymph node yield, postoperative recovery and postoperative complications were observed in the two groups.
UNASSIGNED: There was no statistical difference between the baseline data of the two groups. In relation to the surgery, the observation group had an operation time of 227.0±48.5 minutes, and intraoperative bleeding of 100.0 mL [inter-quartile range (IQR), 30.0-200.0 mL], while the control group had an operation time of 247±41.5 minutes, and intraoperative bleeding of 180.0 mL (IQR, 130.0-245.0 mL). There were statistically significant differences between the two groups in terms of the operation time and intraoperative bleeding (P=0.001, P=0.020). In relation to the LND, there were no statistically significant differences between the two groups in terms of the total number of lymph nodes in each division, and the number of positive lymph nodes. In relation to the post-operative results, there were no statistically significant differences between the two groups in terms of the post-operative pathological stage, first postoperative oral feeding, post-operative hospitalization time, and post-operative complications.
UNASSIGNED: Clockwise modular D2 LND using the \"quadrant-sandwich method\" is potentially safe and feasible in laparoscopic total gastrectomy. It not only ensures the thoroughness of the LND, but also ensures and efficient and fast surgical process, shortens the operation time, and reduces the amount of intraoperative bleeding.

Clinical studies comparing the accuracy of digital and conventional records for static interocclusal registration are lacking. Therefore, the purpose of this clinical study was to assess the precision of digital interocclusal registration compared to conventional registration for full arch and quadrant arch conditions.
Nine individuals with complete natural dentition were enrolled in this study. Each participant received digital scans, conventional impressions, and static interocclusal records according to the following groups: group DF, full arch digital scans and bilateral buccal scans with Medit i700 intraoral scanner (IOS); group DQ, quadrant arch digital scans and unilateral buccal scans with Medit i700 IOS; group CF, full arch polyvinyl siloxane (PVS) impressions and PVS interocclusal records; group CQ, quadrant arch PVS impressions and PVS interocclusal records. For group CF and group CQ, the impressions were poured, mounted with the silicone bites, scanned with a laboratory scanner, and articulated virtually with buccal scans with the laboratory scanner. In each group, each participant received three interocclusal records to repeat the virtual articulation three times and the articulated models were saved as STL files. The STL files were imported into a 3D-processing software to calculate the discrepancies between repeated measures using best-fit-alignment method. The significance between the study groups was calculated with two-tailed paired t-test at P < 0.05.
For full arch, group DF showed significantly better precision with a mean value of 31 ± 19 µm compared to 204 ± 81 µm for group CF (P = 0.0003). Similarly, for quadrant arch, group DQ showed significantly better precision with a mean value of 18 ± 6 µm compared to 255 ± 136 µm for group CQ (P = 0.0009). No significant difference in precision was found between quadrant arch and full arch when the digital or the conventional method was used.
The digital approach had significantly better precision for static interocclusal registration compared to the conventional method in both full and quadrant arch situations. Trial Registry This clinical trial was registered on 06/07/2022 in the Pan African Clinical Trial Registry database, the number for the registry is PACTR202207648490275.

OBJECTIVE: A moderate acute-phase response occurs 24-h following full-mouth non-surgical treatment (FM-SRP). The aim of this study was to compare acute-phase (24-h) and medium-term (3 months) inflammation after quadrant scaling (Q-SRP) versus FM-SRP.
METHODS: Thirty-eight periodontitis-affected subjects were randomly allocated to FM-SRP or Q-SRP after a baseline visit. Periodontal and anthropometric parameters were collected at baseline and 3 months. Serum samples were drawn at baseline, 1, 7, and 90 days after treatment. High-sensitivity assays of inflammation and endothelial assays were performed.
RESULTS: FM-SRP produced a greater acute-phase response after 24 h [threefold increase in C-reactive protein (CRP), twofold increase in interleukin (IL-6), and a slight increase in tumour necrosis factor]. No differences in systemic biomarkers were noted between groups at any later follow-ups. Both periodontal treatments produced a comparable improvement in clinical periodontal parameters with no between-group differences. Treatment time was positively associated with the relative 24-h increase in CRP (R = 0.5, p < 0.001) and IL-6 (R = 0.5, p = 0.002), while the number of deeper (>6 mm) pockets predicted only the relative increase in IL-6 (R = 0.4, p < 0.05).
CONCLUSIONS: FM-SRP triggers a moderate acute-phase response of 24 h duration compared to Q-SRP. Further research is needed to assess the eventual impact of such findings on the risk of vascular events is advocated. (ClinicalTrials.gov NCT01857804).