肺动脉高压(PH)是一种慢性致命疾病,迫切需要新的治疗药物和方法。黄芩素和黄芩苷,中药的活性化合物,黄芩,具有广泛的药理活性。涉及PH的体外和体内模型的大量研究表明,用黄芩苷和黄芩素治疗可能是有效的。本文综述了黄芩苷和黄芩苷对PH有益作用的潜在机制。包括抗炎反应,抑制肺平滑肌细胞增殖和内皮-间质转化,稳定细胞外基质,和缓解氧化应激。还综述了这些化合物的药代动力学。黄芩苷和黄芩素的治疗潜力保证了他们作为PH的自然疗法的持续研究。
Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds of the traditional Chinese medicine, Scutellaria baicalensis Georgi, exhibit a wide range of pharmacological activities. Numerous studies involving in vitro and in vivo models of PH have revealed that the treatment with baicalin and baicalein may be effective. This
review summarizes the potential mechanisms driving the beneficial effects of baicalin and baicalein treatment on PH, including anti-inflammatory response, inhibition of pulmonary smooth muscle cell proliferation and endothelial-to-mesenchymal transformation, stabilization of the extracellular matrix, and mitigation of oxidative stress. The pharmacokinetics of these compounds have also been reviewed. The therapeutic potential of baicalin and baicalein warrants their continued study as natural treatments for PH.