皮肤科假单胞菌瘤（DPM），这是皮肤癣菌的更深的皮肤和/或皮下感染，在韩国国内的短毛猫中很少有报道。一个三岁的孩子,Spyed女性，国内韩国短毛猫提出了一个历史的硬皮，结节,瘙痒1年。在最初的演讲中，在她的腹侧胸腔上发现了覆盖着淡黄色颗粒的多灶性溃疡性结节，腹部，侧翼,和左后肢。溃疡性结节的细胞学显示中性粒细胞变性，巨噬细胞，多核巨细胞,和菌丝。结节的组织学检查显示脓性肉芽肿性皮炎伴真菌斑块，在培养物中鉴定出犬小孢子菌和金黄色葡萄球菌。因此,这只猫被诊断为患有继发性脓皮病的DPM。口服伊曲康唑（10mg/kg，一天一次)被施用，但没有观察到显著的改善。因此,损伤内（IL）注射两性霉素B（0.6mg/结节）和口服特比萘芬（30mg/kg，一天两次)给猫服用。有了这些药物,溃疡和结节的数量和大小显着减少，虽然大的圆顶状结节仍然存在。皮肤病变采用口服特比萘芬和伊曲康唑治疗5个月。然而,6个月后,观察到多灶性溃疡性结节复发，猫在初次陈述后10个月死亡。在这种情况下,IL两性霉素B和口服特比萘芬在DPM治疗中部分有效，这表明这可能是DPM治疗的一种选择。有必要进一步研究以确定IL两性霉素B在DPM管理中的剂量和频率。
Dermatophytic
pseudomycetoma (DPM), which is a deeper dermal and/or subcutaneous infection of dermatophytes, has been rarely reported in Domestic Korean Short Hair Cats. A 3-year-old, spayed female, domestic Korean Short Hair Cat presented with a history of crusts, nodules, and pruritus for 1 year. At the initial presentation, multifocal ulcerative nodules covered with yellowish grains were noted on her ventral thorax, abdomen, flank, and left hindlimb. Cytology of ulcerative nodules revealed degenerative neutrophils, macrophages, multinucleated giant cells, and hyphae. Histological examination of nodules revealed pyogranulomatous dermatitis with fungal plaques, and Microsporum canis and Staphylococcus aureus were identified in the culture. Therefore, the cat was diagnosed with DPM with secondary pyoderma. Oral itraconazole (10 mg/kg, once a day) was administered, but no significant improvement was observed. Therefore, intralesional (IL) injection of amphotericin B (0.6 mg/nodule) and oral administration of terbinafine (30 mg/kg, twice a day) were administered to the cat. With these medications, ulceration and the number and size of nodules decreased significantly, although large dome-shaped nodules remained. Skin lesions were treated with oral terbinafine and itraconazole administration for 5 months. However, after 6 months, recurrence of multifocal ulcerative nodules was observed, and the cat died 10 months after initial presentation. In this
case, IL amphotericin B and oral terbinafine administration were partially effective in DPM treatment, suggesting that this may be an option for DPM treatment. Further studies to determine dose and frequency of IL amphotericin B in the management of DPM are warranted.
PDF(Pubmed)