黄酮类化合物是广泛分布在柑橘属中的天然存在的化合物。这些天然化合物有许多健康益处，主要用于代谢和心血管疾病。事实上,这些化合物中的一些是具有经批准的外周血管功能不全和痔疮适应症的药物产品的成分。然而,关于这些化合物药理作用的信息仍然分散，缺乏对整个数据和证据的全面分析。这些证据分析在糖尿病和高血压的药物设计和创新药物产品的开发中可能是必要的。我们旨在在体内模型中系统地寻找柠檬类黄酮在糖尿病和高血压中功效的证据。我们基于PICO策略搜索了四个文献数据库。在数据库策展之后，检索了29篇文章来分析实验数据。结果和方法均存在高度异质性。在两个实验模型中，柚皮素和橙皮素衍生物是研究最多的柠檬类黄酮。仍需要更多的调查来确定其在药物设计和开发中的潜力。
Flavonoids are naturally occurring compounds widely distributed in the Citrus genus. These natural compounds have many health benefits, mainly for metabolic and cardiovascular diseases. In fact, some these compounds are components of drug products with approved indications for peripheral vascular insufficiency and hemorrhoids. However, information on pharmacological effects of these compounds remains disperse and there is scarce comprehensive analysis of whole data and evidence. These kinds of evidence analyses could be necessary in drug design and the development of novel and innovate drug products in diabetes and hypertension. We aimed to systematically search for evidence on the efficacy of citroflavonoids in diabetes and hypertension in in vivo models. We searched four literature databases based on a PICO strategy. After database curation, twenty-nine articles were retrieved to analyze experimental data. There was high heterogeneity in both outcomes and methodology. Naringenin and hesperetin derivates were the most studied citroflavonoids in both experimental models. More investigation is still needed to determine its potential for drug design and development.
