胞苷5'-二磷酸胆碱在系统性神经退行性疾病中被广泛研究,比如老年痴呆症,帕金森病,和脑缺血。在眼科神经退行性疾病中使用胞磷胆碱的理由,包括青光眼,前部缺血性视神经病变,和糖尿病视网膜病变,建立在其多因素作用机制和参与几种代谢途径的基础上,包括磷脂稳态,线粒体动力学,以及胆碱能和多巴胺能传递,都参与了视觉传播的复杂性。这篇叙述性综述旨在报告关于胞磷胆碱参与此类代谢途径的临床前数据(包括关于其通过与蛋白酶体相互作用在细胞内蛋白质稳定中的作用的新见解)及其对临床心理物理的影响,电生理学,在眼科神经退行性疾病中使用后的形态学结果(包括最近的前瞻性随机临床试验的结果)。
Cytidine 5\'-diphosphocholine has been widely studied in systemic neurodegenerative diseases, like Alzheimer\'s disease, Parkinson\'s disease, and brain ischemia. The rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropathy, and diabetic retinopathy, is founded on its multifactorial mechanism of action and the involvement in several metabolic pathways, including phospholipid homeostasis, mitochondrial dynamics, as well as cholinergic and dopaminergic transmission, all being involved in the complexity of the visual transmission. This narrative
review is aimed at reporting both pre-clinical data regarding the involvement of citicoline in such metabolic pathways (including new insights about its role in the intracellular proteostasis through an interaction with the
proteasome) and its effects on clinical psychophysical, electrophysiological, and morphological outcomes following its use in ophthalmological neurodegenerative diseases (including the results of the most recent prospective randomized clinical trials).