This brief paper describes the challenges with treatment of depression in brain tumour patients particularly in the absence of any currently accepted guidelines for treating this perculiar subset of patients. The proposal offered here is to move to pharmacologic treatment with other modalities in a methodical pattern only after surgical intervention. This is because simply treating with medications based on physician / patient choice as currently recommended may not achieve optimal results in majority of cases in view of the multiple aetiological factors that interplay. A flowchart treatment plan is presented to guide management in a streamlined fashion.

Peer review is the cornerstone in scientific publication. Although peer review has paramount importance in ensuring the quality of the published literature, it still has a number of shortcomings. The present manuscript proposes a new method to improve the current peer review system by providing an interactive, dynamic platform that allows direct, anonymous interaction between the authors of submitted manuscripts and the reviewers. Such real-time interaction may help eliminate any problems related to misunderstanding or misinterpretation of the reviewer\'s comments or the authors\' response, and would save time while keeping the identity of both parties anonymous.