简介和目标近年来，获得性感觉神经性听力损失（SNHL）已成为一个关键的社会问题。SNHL被认为是2型糖尿病（T2DM）的危险因素。二甲双胍常用于治疗2型糖尿病。然而,其对SNHL的影响尚未报道。因此，本研究旨在评估二甲双胍的使用与SNHL发病率之间的相关性.患者和方法在这项回顾性配对队列研究中，对2012年1月1日至2019年12月31日我院住院数据库中1219例年龄>18岁的T2DM患者的病历进行检查,并产生了匹配的队列(76例接受二甲双胍治疗的患者和76例未接受二甲双胍治疗的患者).采用多因素logistic回归分析研究影响SNHL发病的因素。结果经倾向匹配调整后，多变量logistic回归分析显示，不使用二甲双胍会增加发生SNHL的风险(比值比，0.26；95%置信区间，0.07-0.93；p=0.03)。结论：这项研究表明，在T2DM患者中，二甲双胍的使用与SNHL发病率降低之间存在关联。
Introduction and objectives Acquired sensorineural hearing loss (SNHL) has become a critical societal issue in recent years. SNHL is considered a risk factor for type 2 diabetes mellitus (T2DM). Metformin is commonly used to treat T2DM. However, its effects on SNHL have not been reported yet. Hence, this study aimed to evaluate the association between the use of metformin and SNHL incidence. Patients and methods In this retrospective matched-cohort study, the medical records of 1219 patients with T2DM aged >18 years from our hospital\'s inpatient database from January 1, 2012, to December 31, 2019, were examined, and matched cohorts were generated (76 patients receiving metformin and 76 not receiving metformin). A multivariable logistic regression analysis was performed to investigate the factors influencing the incidence of SNHL. Results After adjustment by propensity matching, multivariable logistic regression analysis revealed that the non-use of metformin increased the risk of developing SNHL (odds ratio, 0.26; 95% confidence interval, 0.07-0.93; p = 0.03). Conclusions This study demonstrated an association between the use of metformin and a reduced incidence of SNHL among patients with T2DM.
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