■克雅氏病(CJD)是一种罕见的疾病,迅速进步,和致命的神经退行性疾病。报告的CJD发病率为全球每年每百万人中1至2人,美国每年不到1000例。在这项研究中,我们报告了西密歇根州CJD病例的时间空间集群的独特病例系列。
从2021年7月至2022年6月,在CorewellHealthWest医院共发现了5例CJD病例,由两个时间簇组成。所有病人都做了脑部核磁共振,脑电图,和CSF测试。四名患者接受了尸体解剖。
■所有患者的MRI表现出特征性的CJD模式。四名患者在CSF中具有阳性CJD组。一名患者有典型的CJD脑电图发现。尸检证实4例患者为散发性CJD。所有患者在怀疑CJD后3个月内死亡。
■所有患者都生活在大急流城90英里半径范围内,MI,两个住在同一个县。西密歇根有160万人口,五个患者居住的四个县的总人口为395,104,这表明CJD的新病例率为每百万人中3.1和12.5,分别。CorewellHealth是西密歇根州三大医疗保健系统之一。西密歇根州CJD的实际发病率可能更高。这种密集的CJD病例时空集群构成了严重的公共卫生挑战,需要紧急调查。
UNASSIGNED: Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and uniformly fatal neurodegenerative disease. The reported incidence of CJD is 1 to 2 per million people worldwide annually, with fewer than 1,000 cases in the United States per year. In this study, we report a unique
case series on temporo-spatial clusters of CJD cases in West Michigan.
UNASSIGNED: A total of five CJD cases consisting of two temporal clusters were seen from July 2021 to June 2022 at Corewell Health West hospitals. All patients had brain MRI, EEG, and CSF tests. Four patients underwent autopsies.
UNASSIGNED: All patients\' MRIs showed characteristic CJD patterns. Four patients had positive CJD panels in CSF. One patient had typical CJD EEG findings. Four patients were confirmed as sporadic CJD by autopsy. All patients died within 3 months after CJD was suspected.
UNASSIGNED: All patients lived within a 90-mile radius of Grand Rapids, MI, and two lived in the same county. West Michigan has a population of 1.6 million people, and the four counties where five patients lived have a combined population of 395,104, indicating CJD\'s new
case rate of 3.1 and 12.5 per million people, respectively. Corewell Health is one of the three major healthcare systems in West Michigan. The actual incidence of CJD in West Michigan is likely even higher. This dense temporal and spatial cluster of CJD cases poses a serious public health challenge and warrants urgent investigation.