UNASSIGNED:胃癌肝转移(GCLM)具有高度侵袭性,预后不良。本研究旨在评估原发性肿瘤切除术(PTR)对胃癌肝转移的生存效益。
UNASSIGNED:从监测中提取GCLM患者的数据,流行病学,2010年至2015年的最终结果(SEER)数据库。进行1:1倾向评分匹配(PSM)分析,以最大程度地减少PTR和非PTR组之间的异质性。使用Kaplan-Meier方法和Cox回归分析来评估原发性肿瘤切除术(PTR)对总生存期(OS)和原因特异性生存期(CSS)的影响。
UNASSIGNED:共纳入3,001例GCLM患者,328例患者接受原发性肿瘤切除术(PTR),而其他2,673例患者则没有.在不匹配和PSM队列中,有PTR的患者的OS和CSS率明显高于没有PTR的患者。在一个无与伦比的队列中,接受PTR者的中位OS为12.0个月(95%CI,10个月至14个月),无PTR者为4个月(95%CI,4个月至5个月);接受PTR者的中位CSS为12.0个月(95%CI,10个月至14个月),无PTR者为4个月(95%CI,4个月至5个月),分别。PMS之后,接受PTR的患者的中位OS为12.0个月(95%CI,10个月至17个月),无PTR的患者为7个月(95%CI,5个月至10个月),接受PTR的患者的CSS中位数分别为12.0个月(95%CI,11个月至17个月)和7个月(95%CI,5个月至8个月),分别。此外,PSM队列中的多变量Cox分析显示,PTR,年龄,肿瘤分化程度,化疗是GCLM中OS和CSS的独立预后因素。具体来说,PTR是OS(HR:0.427;95%CI,0.325~0.561,P<0.001)和CSS(HR:0.419;95%CI,0.313~0.561,P<0.001)的显著保护因素。
UNASSIGNED:原发肿瘤切除可提高胃癌肝转移患者的生存率。
UNASSIGNED: Gastric cancer with liver metastasis (GCLM) is highly aggressive and has a poor prognosis. This
study aims to evaluate the survival benefit of primary tumor resection (PTR) for gastric cancer with liver metastasis.
UNASSIGNED: Data on patients with GCLM was extracted from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. A 1:1 propensity score matching (PSM) analysis was performed to minimize the heterogeneity between the PTR and no-PTR groups. The Kaplan-Meier method and Cox regression analysis were used to assess the impact of primary tumor resection (PTR) on overall survival (OS) and cause-specific survival (CSS).
UNASSIGNED: A total of 3,001 patients with GCLM were included, with 328 patients treated with primary tumor resection (PTR), whereas the other 2,673 patients were not. Patients with PTR had a significantly higher OS and CSS rate than those without PTR in unmatched and PSM cohorts. In an unmatched cohort, the median OS was 12.0 months (95% CI, 10 months to 14 months) for those who underwent PTR and 4 months (95% CI, 4 months to 5 months) for those without PTR; the median CSS for those who underwent PTR was 12.0 months (95% CI, 10 months to14 months) and 4 months (95% CI, 4 months to 5 months) for those without PTR, respectively. After PMS, the median OS was 12.0 months (95% CI, 10 months to 17 months) for those who underwent PTR and 7 months (95% CI, 5 months to 10 months) for those without PTR, respectively; the median CSS for those who underwent PTR was 12.0 months (95% CI, 11 months to 17 months) and 7 months (95% CI, 5 months to 8 months) for those without PTR, respectively. In addition, multivariate Cox analysis in the PSM cohort showed that PTR, age, degree of tumor differentiation, and chemotherapy were independent prognostic factors for OS and CSS in GCLM. Specifically, PTR was a significant protective factor for OS (HR: 0.427; 95% CI, 0.325 to 0.561, P <0.001) and CSS (HR: 0.419; 95% CI, 0.313 to 0.561, P <0.001).
UNASSIGNED: Primary tumor resection improves the survival of gastric cancer patients with liver metastasis.