肝硬化(LC)与骨质疏松症的风险增加有关;然而,LC与骨折风险之间的关联尚无定论.因此,本系统综述和荟萃分析旨在探讨LC与骨折风险之间的关系.
为了确定相关文献,系统搜索PubMed,EMBASE,从1965年到2017年7月,进行了Webofscience和Cochrane图书馆,没有语言限制。DerSimonian和Laird描述的随机效应模型用于计算合并比值比(OR)和95%置信区间(CI)。
最终,确定了5项队列研究和3项病例对照研究,其中包括321.035名受试者和31.272例骨折病例。LC与任何骨折风险之间关联的合并OR,髋部骨折,脊柱/躯干骨折和四肢骨折为1.94(95%CI,1.59-2.37),2.11(95%CI,1.34-3.32),2.00(95%CI,1.50-2.67)和1.82(95%CI,1.65-2.01),分别。
总之,这项研究表明,肝硬化患者骨折的风险增加。应尽早采取预防措施。
Liver cirrhosis (LC) was associated with an increased risk of osteoporosis; however, the association between LC and fracture risk was inconclusive. Therefore, this systematic
review and meta-analysis aims to explore the association between LC and fracture risk.
To identify related literature, a systematic search of PubMed, EMBASE, Web of science and the Cochrane Library from 1965 to July 2017 without language limitation was performed. The random-effects model described by DerSimonian and Laird was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Eventually, 5 cohort and 3 case-control studies were identified, which included 321 035 subjects and 31 272 fracture cases. The pooled OR of the association between LC and any fracture risk, hip fracture, spine/trunk fracture and limb fracture was 1.94 (95% CI, 1.59-2.37), 2.11 (95% CI, 1.34-3.32), 2.00 (95% CI, 1.50-2.67) and 1.82 (95% CI, 1.65-2.01), respectively.
In conclusion, this study indicates that cirrhotic patients have an increased risk of fracture. Preventive measures should be instituted as early as possible.