未经证实：没有任何用于诊断听力损失（HL）的常规血清生物标志物。内耳特异性蛋白质,prestin可以作为血清生化标志物用于HL诊断。本研究调查，第一次,伊朗人群中Prestin血清水平与感音神经性HL（SNHL）之间的关系。
方法：在本病例对照研究中，在四组中检查了176个样本，包括两个对照组和两个20-50岁和≥50岁的SNHL组，这些SNHL的严重程度不同。使用人Prestin(SLC26A5)ELISA试剂盒测量血浆Prestin浓度。采用SPSSv.23进行数据分析,显著性水平为0.05。
结果：与对照组（平均值=122.50，SD=57.1）相比，SNHL组具有更高的prestin水平（平均值=182.29，SD=71.24）（P<0.001）。控制干预变量后，prestin水平与SNHL之间关系的多项逻辑回归结果仍然显着（P<0.001，比值比=1.017和95％CIOR：1.01-1.024）。有序logistic回归模型的结果显示，prestin水平与HL程度显着相关（P<0.001，比率=1.009和95％CI，OR：1.005-1.013），因此，HL的可能性随着prestin水平的升高而增加。20-50组的最佳截止点是Prestin含量为132.5pg/ml（灵敏度：75％，特异性：70.05%），而≥50组为130pg/ml(灵敏度：84.1%，特异性：68.2%）。
结论：本研究的结果表明，Prestin是SNHL的有价值的生物标志物。
UNASSIGNED: There is not any routine serum biomarker for diagnosing hearing loss (HL). An inner ear-specific protein,
prestin can be measured as a serum biochemical marker for HL diagnosis. The present
study investigates, for the first time, the relationship between
prestin serum levels and sensorineural HL (SNHL) in an Iranian population.
METHODS: In this case-control
study, 176 samples were examined in four groups including two control and two SNHL groups of 20-50 and ≥ 50 years with different severities of SNHL. Plasma
prestin concentration was measured using Human
Prestin (SLC26A5) ELISA Kit. Data analysis was conducted using SPSS v.23 with level of significance as 0.05.
RESULTS: Groups with SNHL had higher prestin levels (Mean = 182.29, SD = 71.24) compared to the control groups (Mean = 122.50, SD = 57.1) (P < 0.001). Results of the multinomial logistic regression of relationship between prestin level and SNHL remained significant after controlling intervening variables (P < 0.001 and odds ratio = 1.017 and 95% CI OR: 1.01-1.024). Results of the ordinal logistic regression model revealed that prestin level was significantly associated with the degree of HL (P < 0.001 and Odds ratio = 1.009 and 95% CI and OR: 1.005-1.013), so that the likelihood of HL increased with the rise in prestin levels. The best cutoff point for the 20-50 group was the prestin content of 132.5 pg/ml (sensitivity: 75%, specificity: 70.05%), while for the group of ≥ 50 was as 130 pg/ml (sensitivity: 84.1%, specificity: 68.2%).
CONCLUSIONS: Results of the present
study revealed that
prestin acts as a valuable biomarker for SNHL.
