目标:Prader-Willi综合征(PWS)患者的25OHD水平,遗传性肥胖最常见的原因,具有特殊的脂肪量分布,仍在辩论。胰岛素抵抗(IR),体重指数-SDS(BMI-SDS),生长激素治疗(GHT),青春期开始似乎与25OHD水平相互作用。该研究的目的是:(1)与对照组(CNT)相比,分析儿科PWS患者的25OHD水平(2)评估BMI-SDS之间的可能相关性,HOMA-IR,青春期,GHT,和25OHD级别。
方法:这是一个回顾性病例对照,多中心研究。数据收集了8家不同的意大利医院(门诊诊所),为期四年(2016-2020年)。我们纳入了192名遗传证实的PWS和192名CNT患者,3-18岁,匹配1:1的年龄,性别,BMI-SDS,坦纳舞台,阳光照射,一个月的招聘。
结果:在PWS人群和CNT之间观察到25OHD水平没有统计学上的显着差异(PWS24.0ng/mL与CNT22.5ng/mL,P>0.05),OR=0.89(95%CI0.58-1.35)。我们观察到轻微的,虽然不重要,与NW和OB人群相比,25OHD水平降低。HOMA-IR,青春期开始,基因型和GHT(既往或持续)与25OHD水平无统计学显著相关性.
结论:我们的发现可能有助于临床医生优化治疗管理以及提高对PWS的认识。
OBJECTIVE: 25OHD levels in patients with Prader-Willi Syndrome (PWS), the most frequent cause of genetic obesity with a peculiar fat mass distribution, are still debated. Insulin resistance (IR), Body Mass Index-SDS (BMI-SDS), Growth Hormone Therapy (GHT), and puberty onset seem to interact with 25OHD levels. The objectives of the study are: (1) To analyze 25OHD levels in pediatric PWS patients in comparison with a control group (CNT) (2) To evaluate a possible correlation between BMI-SDS, HOMA-IR, puberty, GHT, and 25OHD levels.
METHODS: This is a retrospective
case-control, multicenter study. Data were collected among 8 different Italian Hospitals (outpatient clinics), over a period of four years (2016-2020). We included 192 genetically confirmed PWS and 192 CNT patients, aged 3-18 years, matched 1:1 for age, gender, BMI-SDS, Tanner stage, sun exposure, and month of recruitment.
RESULTS: No statistically significant differences in 25OHD levels were observed between the PWS population and the CNT (PWS 24.0 ng/mL vs CNT 22.5 ng/mL, p > 0.05), OR = 0.89 (95% CI 0.58-1.35). We observed a slight, although non-significant, reduction in 25OHD levels comparing NW and OB populations. HOMA-IR, puberty onset, genotype and GHT (previous or ongoing) did not show statistically significant correlation with 25OHD levels.
CONCLUSIONS: Our findings could be useful for clinicians to optimize the therapeutic management as well as to increase awareness of PWS.