肾脏疾病影响着全球数百万人,是医疗保健系统的经济负担。蛋白磷酸酶2A(PP2A),参与肾脏发育和离子转运蛋白的功能,水通道蛋白-2和足细胞,可能在肾脏过程中起重要作用。PP2A与多种不同肾脏疾病的发病机制有关,包括足细胞损伤,炎症,肿瘤和慢性肾脏疾病。本综述旨在讨论PP2A亚基在肾脏疾病中的结构和功能。讨论了肾脏中PP2A的失调如何导致足细胞死亡和肾癌组织中PP2A的失活。抑制PP2A活性可防止上皮-间质转化并减轻肾脏纤维化,创造良好的炎症微环境,促进肿瘤发病机制的发生和发展。目前的综述还表明,PP2A在预防肾脏炎症中起着重要作用。了解PP2A的详细机制提供了可用于设计和应用治疗和预防肾脏疾病的新疗法的信息。
Kidney disease affects millions of people worldwide and is a financial burden on the healthcare system. Protein phosphatase 2A (PP2A), which is involved in renal development and the function of ion-transport proteins, aquaporin-2 and podocytes, is likely to serve an important role in renal processes. PP2A is associated with the pathogenesis of a variety of different kidney diseases including
podocyte injury, inflammation, tumors and chronic kidney disease. The current
review aimed to discuss the structure and function of PP2A subunits in the context of kidney diseases. How dysregulation of PP2A in the kidneys causes
podocyte death and the inactivation of PP2A in renal carcinoma tissues is discussed. Inhibition of PP2A activity prevents epithelial-mesenchymal transition and attenuates renal fibrosis, creating a favorable inflammatory microenvironment and promoting the initiation and progression of tumor pathogenesis. The current
review also indicates that PP2A serves an important role in protection against renal inflammation. Understanding the detailed mechanisms of PP2A provides information that can be utilized in the design and application of novel therapeutics for the treatment and prevention of renal diseases.