背景:有几种方法可以测量早产儿的身体成分。然而,没有关于哪种方法应该是首选的协议。
方法:PubMed,Embase.com,Wiley/Cochrane图书馆,和GoogleScholar进行了搜索,以获取有关早产中身体成分测量的预测价值或有效性的研究报告,校正年龄6个月。
结果:纳入了1884项确定的研究中的19项。基于权重和长度指数的预测方程,身体面积,皮褶厚度,生物电阻抗,超声与用空气置换体积描记术(ADP)测量的身体成分不一致,双能X射线吸收法(DXA),磁共振成像(MRI),或同位素稀释。ADP与同位素稀释测得的脂肪质量密度吻合良好(偏差-0.002g/ml,协议限值±0.012g/ml,n=14)。用ADP测量的脂肪质量百分比与通过同位素稀释测量的脂肪质量百分比不一致(一致极限高达5.8%),并且测量之间的偏差高达2.2%。DXA,MRI,和同位素稀释在早产中未与另一种参考方法进行比较。
结论:DXA,ADP,和同位素稀释方法被认为是值得信赖的验证技术。然而,这篇综述表明,这些方法可能无法产生可比的结果。
结论:基于在有限数量的研究对象中进行的验证研究,重量和长度指数,身体面积,皮褶厚度,生物电阻抗,和超声波似乎是早产儿身体成分的不良表现。DXA,ADP,和同位素稀释方法被认为是值得信赖和验证的技术。然而,这些方法可能无法产生可比的结果。
There are several methods to measure body composition in preterm infants. Yet, there is no agreement on which method should be preferred.
PubMed, Embase.com, Wiley/Cochrane Library, and Google Scholar were searched for studies that reported on the predictive value or validity of body composition measurements in preterms, up to 6 months corrected age.
Nineteen out of 1884 identified studies were included. Predictive equations based on weight and length indices, body area circumferences, skinfold thickness, bioelectrical impedance, and ultrasound did not show agreement with body composition measured with air displacement
plethysmography (ADP), dual-energy x-ray absorptiometry (DXA), magnetic resonance imaging (MRI), or isotope dilution. ADP agreed well with fat mass density measured by isotope dilution (bias -0.002 g/ml, limits of agreement ±0.012 g/ml, n = 14). Fat mass percentage measured with ADP did not agree well with fat mass percentage measured by isotope dilution (limits of agreement up to ±5.8%) and the bias between measurements was up to 2.2%. DXA, MRI, and isotope dilution were not compared to another reference method in preterms.
DXA, ADP, and isotope dilution methods are considered trustworthy validated techniques. Nevertheless, this
review showed that these methods may not yield comparable results.
Based on validation studies that were conducted in a limited number of study subjects, weight and length indices, body area circumferences, skinfold thickness, bioelectrical impedance, and ultrasound seem to be a poor representation of body composition in preterm infants. DXA, ADP, and isotope dilution methods are considered trustworthy and validated techniques. Nevertheless, these methods may not yield comparable results.