Pimavanserin是一种抗精神病药，被批准用于帕金森病精神病。作为血清素2A反向激动剂，pimavanserin可以改善患者的精神病症状，而不会使帕金森病的运动症状恶化。这种机制是通过5-羟色胺受体介导的，并且可以考虑将匹马色林用于精神病患者的其他疾病过程。这里,作者描述了一例75岁的路易体痴呆(LBD)患者开始服用吡马色林的病例.使用精神分裂症阳性症状评估量表（SAPS），在六周的时间内测量患者对药物的反应。总的来说,吡马色林被证明对患有LBD的患者有效。作者还提供了对稀疏文献的综述，这些文献证明了这种独特的抗精神病药的其他标签外用途。
Pimavanserin is an antipsychotic that is approved for use in Parkinson\'s disease psychosis. Working as a serotonin 2A inverse agonist, pimavanserin allows patients to improve their psychotic symptoms without worsening the motor symptoms of Parkinson\'s. This mechanism is mediated via serotonin receptors and may allow for
pimavanserin to be considered for use in other disease processes that present with psychosis. Here, the authors describe the
case of a 75-year-old man with Lewy Body Dementia (LBD) who was started on
pimavanserin. The response of the patient to the medication was measured over a six-week time course using the Scales for the Assessment of Positive Symptoms of Schizophrenia (SAPS). Overall,
pimavanserin was shown to be effective in this patient with LBD. The authors also provide a review of the sparse literature attesting to other off-label uses for this unique antipsychotic.
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