恶性毛囊肿瘤是罕见的皮肤附件恶性肿瘤,对头颈部区域有好感。它们可以分为许多不同的亚型。组织学上,他们不同于他们的良性对应物。据我们所知,没有对这些恶性肿瘤进行广泛的审查,尤其是在眶周区。我们的目标是为眶周区域的这些恶性肿瘤的治疗提供文献综述和指南。Medline的数据库,PubMed,Embase,和谷歌学者进行了咨询。本综述共纳入16例眶周区毛囊恶性肿瘤文献。临床表现,诊断模式,使用的调查,并讨论了这些肿瘤的最佳治疗方法。美国癌症联合委员会(AJCC)第7版眼睑癌分期系统用于描述他们的行为。我们建议对这些肿瘤进行广泛切除手术和密切随访。晚期的肿瘤需要对远处转移进行检查,并考虑进行切除手术。放疗和化疗在这种情况下的作用仍不确定。
Malignant hair follicle tumors are rare skin adnexal malignancies that have a predilection for the head and neck region. They can be categorized into a number of different subtypes. Histologically, they are distinct from their benign counterpart. To the best of our knowledge, there is no extensive review of these malignancies, especially in the periorbital region. We aim to provide a literature review and a
guideline for management of these malignant tumors in the periorbital region. Database from Medline, PubMed, Embase, and Google Scholar were consulted. A total of 16 cases from the literature on hair follicle malignancies in the periorbital region were included in this review. The clinical presentations, diagnostic patterns, investigations used, and best management approach of these tumors are discussed. The American Joint Committee on Cancer (AJCC) 7(th) edition carcinoma of the eyelid staging system was used to describe their behaviors. We recommend wide excision surgery and a close follow-up for these tumors. Tumors presenting with a late stage require work-up for distant metastasis and consideration for exenteration procedures. The role of radiotherapy and chemotherapy in this context is still uncertain.