背景:自体非培养的黑素细胞角质形成细胞移植程序(MKTP)已成为一种流行的移植技术,具有获得色素恢复的功效。然而,对于实现可接受的再色素沉着所需的最佳受体与供体(RD)比例,目前尚无共识.在这项120例患者的回顾性队列研究中,我们试图研究扩张比是否会影响MKTP后的再色素沉着成功率.
结果:共有69名患者(平均[SD]年龄为32.4[14.3]岁,平均随访时间为30.4[22.5]个月,63.8%为男性;55%为深色皮肤个体[FitzpatrickIV-VI])。在局灶性/节段性白癜风(SV)患者中,白癜风区域评分指数(VASI)的平均百分比变化为80.2(±23.7;RD为7.3),非节段白癜风(NSV)患者为58.3(±33.0;RD为8.2),和51.8(±33.6;RD为3.7)在那些患有白斑病和piebaldism的人中。Focal/SV与较高的VASI百分比变化呈正相关(参数估计:22.6,p值0.005)。在SV/病灶组中,与白人相比,非白人患者的RD比率更高(8.2±3.4vs.分别为6.0±3.1,p值=0.035)。
结论:在我们的研究中,我们发现,与患有NSV的患者相比,患有SV的患者更有可能实现更高的色素沉着率.尽管低膨胀比组的色素沉着率高于高膨胀比组,我们没有观察到两组之间的显著差异.
结论:MKTP是一种恢复稳定性白癜风患者色素沉着的有效疗法。白癜风对MKTP的治疗反应似乎受白癜风类型的影响,而不是特定的RD比率。
BACKGROUND: The autologous noncultured melanocyte keratinocyte transplant procedure (MKTP) has emerged as a popular grafting technique with proven efficacy for achieving repigmentation. However, there remains no consensus regarding the optimal recipient-to-donor (RD) ratio required to achieve acceptable repigmentation. In this retrospective cohort study of 120 patients, we sought to examine whether expansion ratios impact the repigmentation success rates following MKTP.
RESULTS: A total of 69 patients (mean [SD] age was 32.4 [14.3] years, mean follow-up was 30.4 [22.5] months, 63.8% were male; 55% were dark-skinned individuals [Fitzpatrick IV-VI]) were included. The mean percent change in the Vitiligo Area Scoring Index (VASI) was 80.2 (±23.7; RD of 7.3) in patients with focal/segmental vitiligo (SV), 58.3 (±33.0; RD of 8.2) in those with non-segmental vitiligo (NSV), and 51.8 (±33.6; RD of 3.7) in those with leukoderma and
piebaldism. Focal/SV was positively associated with a higher percent change in VASI (parameter estimate: 22.6, p value <0.005). In the SV/focal group, non-white patients had a higher RD ratio compared to White individuals (8.2 ± 3.4 vs. 6.0 ± 3.1, respectively, p value = 0.035).
CONCLUSIONS: In our study, we found that patients with SV were significantly more likely to achieve higher repigmentation rates compared to those with NSV. Although repigmentation rates were higher in the low expansion ratio group than in the high expansion ratio group, we did not observe a significant difference between the two groups.
CONCLUSIONS: MKTP is an effective therapy for restoring repigmentation in patients with stable vitiligo. Therapeutic response of vitiligo to MKTP appears to be influenced by the type of vitiligo, rather than a specific RD ratio.