■由于造成这种现象的复杂的细胞和分子变化,皮肤光老化的机制仍然难以捉摸,还有待阐明。在光老化中,角质形成细胞和成纤维细胞的作用对于维持皮肤结构和弹性至关重要。但是这些细胞在光老化过程中会受到光诱导的损伤,引起皮肤形态变化.最近,天然活性成分在治疗和预防光老化方面的作用越来越受到重视,研究通常集中在角质形成细胞和成纤维细胞上。
■我们搜索了2007年至2024年1月在WebofScience上发表的研究,PubMed,和ScienceDirect数据库通过以下关键词:天然植物,天然植物产品或植物化学物质,中药或中草药,植物提取物,太阳能皮肤老化,皮肤光老化,和皮肤起皱。这项审查是根据系统审查和荟萃分析指南的首选报告项目进行的。
■总共,本综述包括87项研究(图1)。在角质形成细胞中,天然化合物可能主要调节信号通路,如NF-κB,MAPK,PI3K/AKT,和Nrf2/ARE通路,减少炎症和细胞损伤,从而减缓皮肤光老化。此外,在成纤维细胞中,天然活性成分主要促进TGF-β途径,抑制MMPs活性,并增强胶原蛋白合成,同时可能调节mTOR途径,从而保护真皮胶原蛋白网络和减少皱纹的形成。几项试验表明,调节角质形成细胞和成纤维细胞反应的天然化合物具有显著且安全的治疗效果。
■防晒制剂中基于天然产品的成分的需求正在上升。天然化合物通过靶向角质形成细胞和成纤维细胞的细胞途径显示出有希望的抗光老化作用。提供潜在的治疗策略。然而,需要全面的临床研究来验证它们在减轻光老化方面的功效和安全性,应使用先进的药理学方法来揭示天然化合物的复杂抗光老化机制。
UNASSIGNED: The mechanism underlying skin
photoaging remains elusive because of the intricate cellular and molecular changes that contribute to this phenomenon, which have yet to be elucidated. In
photoaging, the roles of keratinocytes and fibroblasts are vital for maintaining skin structure and elasticity. But these cells can get photo-induced damage during
photoaging, causing skin morphological changes. Recently, the function of natural active ingredients in treating and preventing
photoaging has drawn more attention, with researches often focusing on keratinocytes and fibroblasts.
UNASSIGNED: We searched for studies published from 2007 to January 2024 in the Web of Science, PubMed, and ScienceDirect databases through the following keywords: natural plant, natural plant products or phytochemicals, traditional Chinese Medicine or Chinese herbal, plant extracts, solar skin aging, skin photoaging, and skin wrinkling. This review conducted the accordance of Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.
UNASSIGNED: In total, 87 researches were included in this review (Figure 1). In keratinocytes, natural compounds may primarily regulate signal pathways such as the NF-κB, MAPK, PI3K/AKT, and Nrf2/ARE pathways, reducing inflammation and cellular damage, thus slowing skin photoaging. Additionally, in fibroblasts, natural active ingredients primarily promote the TGF-β pathway, inhibit MMPs activity, and enhance collagen synthesis while potentially modulating the mTOR pathway, thereby protecting the dermal collagen network and reducing wrinkle formation. Several trials showed that natural compounds that regulate keratinocytes and fibroblasts responses have significant and safe therapeutic effects.
UNASSIGNED: The demand for natural product-based ingredients in sunscreen formulations is rising. Natural compounds show promising anti-photoaging effects by targeting cellular pathways in keratinocytes and fibroblasts, providing potential therapeutic strategies. However, comprehensive clinical studies are needed to verify their efficacy and safety in mitigating photoaging, which should use advanced pharmacological methods to uncover the complex anti-
photoaging mechanisms of natural compounds.