背景:尽管苯妥英对伤口愈合有潜在的益处,疼痛缓解,以前已经报道过各种伤口类型的感染控制,它在伤口护理中的使用仍然有限。
目的:进行全面综述,以评估局部用苯妥英与标准和替代治疗方法对不同伤口类型的疗效。
方法:作者最后一次搜索Cochrane图书馆,PubMed,PubMedCentral,和MEDLINE在2023年6月。包括任何时候的所有英语人类RCT和NRCT。RoB2用于评估随机试验的质量,使用ROBINS-I评估非随机试验的质量.包括不超过1个领域的低偏倚风险或一些担忧的研究。收集和分析的数据包括伤口类型,干预措施,样本量,结果衡量标准,和不利影响。
结果:搜索产生了101项研究,其中17项RCT和8项NRCT符合纳入条件.在纳入的研究中,56%的人在所有领域都有较低的偏倚风险。样本量在20到130之间变化(中位数,60),总样本量为1653例。苯妥英改善了伤口愈合的24项研究中的17项(71%),在评估肉芽组织的10项研究中有9项增加(90%),在评估它的13项研究中的7项(54%)提供了镇痛作用,并在8项评估它的研究中的6项(75%)中抑制了细菌污染物。不良反应很少见(29%),最小,和短暂的。
结论:苯妥英可促进伤口愈合,并提供镇痛和抗菌特性,副作用最小。需要进一步研究苯妥英的最佳剂量,以及频率,送货车辆,以及对其他术后伤口的影响。
背景:尽管苯妥英对伤口愈合有潜在的益处,疼痛缓解,以前已经报道过各种伤口类型的感染控制,它在伤口护理中的使用仍然有限。
目的:进行全面综述,以评估局部用苯妥英与标准和替代治疗方法对不同伤口类型的疗效。
方法:作者最后一次搜索Cochrane图书馆,PubMed,PubMedCentral,和MEDLINE在2023年6月。包括任何时候的所有英语人类RCT和NRCT。RoB2用于评估随机试验的质量,使用ROBINS-I评估非随机试验的质量.包括不超过1个领域的低偏倚风险或一些担忧的研究。收集和分析的数据包括伤口类型,干预措施,样本量,结果衡量标准,和不利影响。
结果:搜索产生了101项研究,其中17项RCT和8项NRCT符合纳入条件.在纳入的研究中,56%的人在所有领域都有较低的偏倚风险。样本量在20到130之间变化(中位数,60),总样本量为1653例。苯妥英改善了伤口愈合的24项研究中的17项(71%),在评估肉芽组织的10项研究中有9项增加(90%),在评估它的13项研究中的7项(54%)提供了镇痛作用,并在8项评估它的研究中的6项(75%)中抑制了细菌污染物。不良反应很少见(29%),最小,和短暂的。
结论:苯妥英可促进伤口愈合,并提供镇痛和抗菌特性,副作用最小。需要进一步研究苯妥英的最佳剂量,以及频率,送货车辆,以及对其他术后伤口的影响。
BACKGROUND: Although
phenytoin\'s potential benefits in wound healing, pain relief, and infection control across various wound types have been previously reported, its use in wound care remains limited.
OBJECTIVE: To conduct a comprehensive
review to assess the efficacy of topical
phenytoin compared with standard and alternative treatments for different wound types.
METHODS: The authors last searched Cochrane Library, PubMed, PubMed Central, and MEDLINE in June 2023. All English-language human RCTs and NRCTs from any time were included. The RoB 2 was used to assess quality of randomized trials, and the ROBINS-I was used to assess the quality of nonrandomized trials. Studies with a low risk of bias or some concerns in no more than 1 domain were included. Data collected and analyzed included wound type, interventions, sample size, outcome measures, and adverse effects.
RESULTS: The search yielded 101 studies, of which 17 RCTs and 8 NRCTs were eligible for inclusion. Of the included studies, 56% had a low risk of bias in all domains. The sample sizes varied between 20 and 130 (median, 60), with a total sample size of 1653 patients.
Phenytoin improved wound healing in 17 of the 24 studies that evaluated it (71%), increased granulation tissue in 9 of the 10 studies that evaluated it (90%), provided analgesic effects in 7 of the 13 studies that evaluated it (54%), and inhibited bacterial contaminants in 6 of the 8 studies that evaluated it (75%). Adverse effects were rare (29%), minimal, and transient.
CONCLUSIONS: Phenytoin enhances wound healing and offers analgesic and antibacterial properties with minimal adverse effects. Further research is needed on optimal dosage of
phenytoin, as well as frequency, delivery vehicles, and effects on other postoperative wounds.
BACKGROUND: Although
phenytoin\'s potential benefits in wound healing, pain relief, and infection control across various wound types have been previously reported, its use in wound care remains limited.
OBJECTIVE: To conduct a comprehensive
review to assess the efficacy of topical
phenytoin compared with standard and alternative treatments for different wound types.
METHODS: The authors last searched Cochrane Library, PubMed, PubMed Central, and MEDLINE in June 2023. All English-language human RCTs and NRCTs from any time were included. The RoB 2 was used to assess quality of randomized trials, and the ROBINS-I was used to assess the quality of nonrandomized trials. Studies with a low risk of bias or some concerns in no more than 1 domain were included. Data collected and analyzed included wound type, interventions, sample size, outcome measures, and adverse effects.
RESULTS: The search yielded 101 studies, of which 17 RCTs and 8 NRCTs were eligible for inclusion. Of the included studies, 56% had a low risk of bias in all domains. The sample sizes varied between 20 and 130 (median, 60), with a total sample size of 1653 patients.
Phenytoin improved wound healing in 17 of the 24 studies that evaluated it (71%), increased granulation tissue in 9 of the 10 studies that evaluated it (90%), provided analgesic effects in 7 of the 13 studies that evaluated it (54%), and inhibited bacterial contaminants in 6 of the 8 studies that evaluated it (75%). Adverse effects were rare (29%), minimal, and transient.
CONCLUSIONS: Phenytoin enhances wound healing and offers analgesic and antibacterial properties with minimal adverse effects. Further research is needed on optimal dosage of
phenytoin, as well as frequency, delivery vehicles, and effects on other postoperative wounds.