■本研究旨在系统评价帕金森病(PD)运动临床表型与喉疾病症状之间的关联。喉功能障碍如发音障碍和吞咽困难在帕金森病(PwPD)患者中普遍存在。与其他疾病症状相似,它们在整个PwPD中表现不同。PD内的一些变异性已由临床表型解释。然而,目前尚不清楚PD的喉症状在这些表型中如何表达.
■搜索了五个数据库(MEDLINE,CINAHL,WebofScience,Embase,Scopus),2022年5月。删除副本后,对所有检索到的记录进行筛选.队列,病例控制,包括讨论喉症状和临床PD表型的英文横断面研究。数据被提取,列表,并使用Moola等人进行评估。(2021年)用于风险和病因系统评价的评估工具。
■搜索检索到2370条记录,代表540PwPD.删除副本并进行筛选后,纳入了八篇文章进行审查。最常见的表型类别是震颤显性和姿势不稳定步态紊乱(PIGD)。五项研究涉及声乐特征,而四个人考虑吞咽。不同研究的方法论差异和缺乏严谨性复杂的结论,但是发现了以震颤为主的表型呈现较不严重的喉症状的趋势。
■在PD的震颤显性表型和PIGD表型之间发现了喉功能的一些微小差异。然而,在比较喉功能的运动表型时,需要更标准化和高质量的研究.
UNASSIGNED: This study aimed to systematically
review the associations between motor clinical
phenotypes in Parkinson\'s disease (PD) and laryngeal disease symptoms. Laryngeal dysfunctions such as dysphonia and dysphagia are ubiquitous in people with Parkinson\'s disease (PwPD). Similar to other disease symptoms, they manifest variably across PwPD. Some of the variability within PD has been explained by clinical
phenotypes. However, it is unclear how laryngeal symptoms of PD express themselves across these
phenotypes.
UNASSIGNED: Five databases were searched (MEDLINE, CINAHL, Web of Science, Embase, Scopus) in May 2022. After the removal of duplicates, all retrieved records were screened. Cohort, case-control, and cross-sectional studies in English discussing laryngeal symptoms and clinical PD phenotypes were included. Data were extracted, tabulated, and assessed using Moola et al.\'s (2021) appraisal tool for systematic reviews of risk and etiology.
UNASSIGNED: The search retrieved 2370 records, representing 540 PwPD. After the removal of duplicates and screening, eight articles were included for
review. The most common phenotype categories were tremor-dominant and postural-instability gait disordered (PIGD). Five studies addressed vocal characteristics, while four considered swallowing. Differences and lack of rigor in methodology across studies complicated conclusions, but a tendency for tremor-dominant phenotypes to present with less severe laryngeal symptoms was found.
UNASSIGNED: Some minor differences in laryngeal function were found between tremor-dominant and PIGD phenotypes in PD. However, there is a need for more standardized and high-quality studies when comparing motor phenotypes for laryngeal function.