产前暴露于个人护理产品的内分泌干扰化学物质(EDC)可能与早产和低出生体重等出生结局有关。研究怀孕期间使用个人护理产品对分娩结果的作用的研究有限。我们的试点研究包括环境生殖和葡萄糖结果(ERGO)研究的164名参与者(波士顿,MA),在整个怀孕期间四次研究访视时自我报告的个人护理产品使用情况(研究访视前48小时的产品使用情况和研究访视前一个月的头发产品使用情况)。我们使用协变量调整线性回归模型来估计分娩时平均胎龄的差异,出生长度,和基于个人护理产品使用的性别特定出生体重胎龄(BW-for-GA)Z评分。在某些研究访问之前的过去一个月中使用头发产品与降低的平均性别特异性BW-for-GAZ-得分相关。值得注意的是,研究访视1前1个月使用发油与未使用发油相比,平均BW-for-GAZ-评分较低(V1:-0.71,95%置信区间:-1.12,-0.29).在所有研究访视(V1-V4)中,在指甲油使用者中观察到平均出生长度增加与非用户。相比之下,剃须膏使用者与剃须膏使用者的平均出生长度减少非用户。液体肥皂,洗发水,某些研究访视时使用调理剂与较高的平均出生身长显著相关.在其他产品的研究访问中观察到了暗示性关联,包括具有BW-for-GAZ-score的发胶/喷雾剂和液体/条皂与胎龄。总的来说,观察到在整个怀孕期间使用各种个人护理产品与我们感兴趣的分娩结果有关,特别是在怀孕早期使用头发油。这些发现可能有助于为未来的干预措施/临床建议提供信息,以减少与不良妊娠结局相关的暴露。
Prenatal exposure to endocrine disrupting chemicals (EDCs) from personal care products may be associated with birth outcomes including preterm birth and low birth weight. There is limited research examining the role of personal care product use during pregnancy on birth outcomes. Our pilot
study consisted of 164 participants in the Environmental Reproductive and Glucose Outcomes (ERGO)
study (Boston, MA), with data on self-reported personal care product use at four
study visits throughout pregnancy (product use in the 48 h before a
study visit and hair product use in the month before a
study visit). We used covariate-adjusted linear regression models to estimate differences in mean gestational age at delivery, birth length, and sex-specific birth weight-for-gestational age (BW-for-GA) Z-score based on personal care product use. Hair product use in the past month prior to certain study visits was associated with decreased mean sex-specific BW-for-GA Z-scores. Notably, hair oil use in the month prior to
study visit 1 was associated with a lower mean BW-for-GA Z-score (V1: -0.71, 95% confidence interval: -1.12, -0.29) compared to non-use. Across all study visits (V1-V4), increased mean birth length was observed among nail polish users vs. non-users. In comparison, decreased mean birth length was observed among shave cream users vs. non-users. Liquid soap, shampoo, and conditioner use at certain study visits were significantly associated with higher mean birth length. Suggestive associations were observed across study visits for other products including hair gel/spray with BW-for-GA Z-score and liquid/bar soap with gestational age. Overall, use of a variety of personal care products throughout pregnancy was observed to be associated with our birth outcomes of interest, notably hair oil use during early pregnancy. These findings may help inform future interventions/clinical recommendations to reduce exposures linked to adverse pregnancy outcomes.