目的:评估子宫内膜异位症(EMs)是否与分化簇(CD)4+T细胞的系统和/或局部偏差有关。
方法:直到2022年11月,我们共纳入了来自32项符合纳入标准的研究的1363名EMs和1564名健康女性。
结果:在系统地检索文献后,我们纳入了1086篇引文和32项病例对照研究.累积结果表明,EMs和健康女性之间外周血(PB)中CD4T细胞的差异不明显(RR:-0.83,I2=99%,p=0.65),轻度和重度EMs之间也没有统计学上的显着差异(RR:3.19,I2=94%,p=0.19)。我们还发现EMs和健康女性在PB期间CD4+/CD8+的差异不显著(RR:0.09,I2=99%,p=0.39),在轻度和重度EMs之间(RR:-0.16,I2=99%,p=0.29)。结果可能表明EMs与CD4T细胞的系统偏差之间没有显着相关性。当出现腹腔积液(PF)时,调查结果表明,在EMs期间CD4+T细胞的频率明显低于健康女性(RR:-5.38,I2=93%,p=0.01),EMs期间CD4+/CD8+比值明显低于健康女性(RR:-0.13,I2=0%,p<0.0001)。然而,在轻度和重度EMs之间,PF期间CD4+的差异不显著(RR:1.65,I2=53%,p=0.15),此外,轻度和重度EMs之间的CD4/CD8+差异不显著(RR:-0.09,I2=14%,p=0.19)。EMs可能与CD4+T细胞的局部偏离密切相关。
结论:EMs与CD4+T细胞系统偏差无明显相关性,EMs可能与CD4+T细胞的局部偏离密切相关。迫切需要进一步研究CD4+T细胞的功能偏差和亚群分布。
To assess whether endometriosis (EMs) was related to systematic and/or local deviations of cluster of differentiation (CD)4 + T cells.
Until November 2022, we enrolled a total of 1363 EMs and 1564 healthy women from 32 studies who met the inclusion criteria.
After systematically retrieving the literature, we identified 1086 citations and 32 case-control studies were enrolled. Cumulative results suggested that there were insignificant deviations of CD4 + T cells during peripheral blood (PB) between EMs and healthy women (RR: - 0.83, I2 = 99%, p = 0.65), also no statistically significant difference was found between mild and severe EMs (RR: 3.19, I2 = 94%, p = 0.19). We also found insignificant deviations of CD4 + /CD8 + during PB between EMs and healthy women (RR: 0.09, I2 = 99%, p = 0.39), and between mild and severe EMs (RR: - 0.16, I2 = 99%, p = 0.29). The results might suggest that there was no significant correlation between EMs and systematic deviations of CD4 + T cells. When it came to local deviation during peritoneal fluid (PF), the polled results suggested that the frequency of CD4 + T cells during EMs was significantly lower than healthy women (RR: - 5.38, I2 = 93%, p = 0.01), and the ratio of CD4 + /CD8 + during EMs was significantly lower than healthy women (RR: - 0.13, I2 = 0%, p < 0.0001). However, there were insignificant deviations of CD4 + during PF between mild and severe EMs (RR: 1.65, I2 = 53%, p = 0.15), also there was an insignificant difference of CD4 + /CD8 + between mild and severe EMs (RR: - 0.09, I2 = 14%, p = 0.19). EMs might be closely related to local deviations of CD4 + T cells.
There was no obvious correlation between EMs and systematic deviations of CD4 + T cells, EMs might be closely related to local deviations of CD4 + T cells. Further study on the functional deviations and subpopulation distribution of CD4 + T cells is urgently needed.