案例1,一个6岁的孩子,撒尿的雌性帕格,出现严重的系统性荨麻疹,水肿,和红斑.这只狗在另一家医院接受了法莫替丁注射液作为反复呕吐的治疗。在体检时,观察到热疗。中度全血细胞减少症,低蛋白血症,在血液检查中也观察到CRP和D-二聚体升高。低尿性蛋白尿,肺间质浸润,在其他测试中发现了肝肿大。在皮肤的组织学中,观察到皮肤水肿和炎症细胞浸润。因此,她被诊断为急性全身超敏反应。案例2,一个13个月大的孩子,绝育的雄性彭布罗克威尔士柯基,表现为严重和斑片状的系统性溃疡性皮肤病变。该狗在2天前有软粪便和肛门周围疼痛的病史。血小板减少症,在血液检查中观察到CRP和D-二聚体升高。在组织学上,表皮坏死松解症,表皮和真皮的分离,观察到炎症细胞浸润。因此,他被诊断出患有免疫介导的坏死松解性皮炎。案例3,一个12岁的孩子,斯派的女性波美拉尼亚,出现严重的全身性脱发,脓包,和皮肤上的外壳。这只狗接受了当地医院的感染治疗。严重的再生性贫血(血细胞比容15.3%,阴性盐水凝集试验,阴性载玻片凝集试验,Coomb测试阴性,突出的球形细胞)肝酶升高,在血液检查中观察到CRP和D-二聚体升高。关于皮肤的组织病理学,脓疱,棘层松解细胞,在上皮的角蛋白层中观察到炎症细胞。因此,她被诊断为天疱疮并伴有免疫介导的溶血性贫血.3例诊断为致命的免疫介导性皮肤病,并伴有血液学和全身性异常。所有病例均给予免疫抑制药物治疗,泼尼松龙,和环孢菌素.在病例2和3中,狗还接受人静脉内免疫球蛋白作为免疫调节剂。治疗成功,所有3例患者均有显着改善。
Case 1, a 6-year-old, spayed female Pug, presented with severe systemic urticaria, edema, and erythema. The dog had received a famotidine injection as a treatment for repeated vomiting in another hospital. On physical examination, hyperthermia was observed. Moderate pancytopenia, hypoalbuminemia, and increased CRP and D-dimer were also observed in blood tests. Hyposthenuric proteinuria, pulmonary interstitial infiltration, and hepatomegaly were found in other tests. In the histology of the skin, dermal edema and infiltration of inflammatory cells were observed. Therefore, she was diagnosed with acute systemic hypersensitivity.
Case 2, a 13-month-old, neutered male Pembroke welsh corgi, presented with severe and patchy systemic ulcerative skin lesions. The dog had a history of soft feces and pain around the anus 2 days before. Thrombocytopenia, and increased CRP and D-dimer were observed in blood tests. In histology, epidermal necrolysis, separation of the epidermis and dermis, and infiltration of inflammatory cells were observed. Therefore, he was diagnosed with an immune-mediated disease with necrolysis dermatitis.
Case 3, a 12-year-old, spayed female Pomeranian, presented with severe systemic alopecia, pustule, and crust on the skin. The dog had received an infection treatment from a local hospital. Severe regenerative anemia (hematocrit 15.3%, negative saline agglutination test, negative slide agglutination test, negative Coomb\'s test, prominent spherocytes) elevated liver enzymes, and increased CRP and D-dimer were observed in blood tests. On histopathology of the skin, pustules, acantholytic cells, and inflammatory cells were observed in the keratin layer of the epithelium. Therefore, she was diagnosed with Pemphigus foliaceus concurrent with immune-mediated hemolytic anemia. The 3 cases were diagnosed with fatal immune-mediated skin disease concurrently with hematological and systemic abnormalities. All the cases were treated with immune-suppressive drugs, prednisolone, and cyclosporine. In cases 2 and 3, the dogs also received human intravenous immunoglobulin as an immune modulator. The treatment was successful with significant improvements in all the 3 cases.