婴儿期维生素D缺乏与骨转换率和骨矿物质流失增加有关。然而,很少有研究检测维生素D缺乏婴儿骨形成和骨吸收的骨转换标志物(BTMs)。这里,我们分析了25OHD的血清浓度,完整的副激素(iPTH),和BTMs,包括总碱性磷酸酶(ALP),抗酒石酸酸性磷酸酶同工型5b(TRACP-5b),Sa玉市医院出生的456名年龄小于12个月的婴儿(626个样本)的血清I型胶原N-端肽(NTx)以及基本临床特征,日本(北纬35.9°),2021年1月至2022年12月。116名婴儿(147个样本)被归类为维生素D缺乏症(25OHD<12.0ng/mL),和340名婴儿(479份样本)有足够的维生素D水平(25OHD≥12.0ng/mL).除了25OHD和ALP,在331名婴儿(418个样本)中测量了TRACP-5b和sNTx,而90名婴儿(105个样本)仅测量了TRACP-5b,101名婴儿(103个样本)仅测量了sNTx.在匹配背景特征后,对维生素D缺乏和充足组的104名受试者进行统计比较,发现维生素D缺乏组的ALP和iPTH水平明显高于充足组(分别为P=<.0001,.0012)。然而,两组间TRACP-5b和NTx水平无显著差异(P分别为.19,.08).我们的发现表明,在婴儿期亚临床维生素D缺乏中,骨形成和吸收标志物之间的反应不一致。
Vitamin D deficiency during infancy has been associated with increased bone turnover rate and bone mineral loss. However, few studies have examined bone turnover markers (BTMs) for both bone formation and resorption in infants with vitamin D deficiency. Here, we analyzed serum concentrations of 25OHD, intact parathormone (iPTH), and BTMs including total alkaline phosphatase (ALP), tartrate-resistant acid phosphatase isoform 5b (TRACP-5b), and serum type I collagen N-telopeptide (NTx) as well as basic clinical characteristics of 456 infants (626 samples) aged less than 12 mo born at Saitama City Hospital, Japan (latitude 35.9° North) between January 2021 and December 2022. One hundred sixteen infants (147 samples) were classified as having vitamin D deficiency (25OHD < 12.0 ng/mL), and 340 infants (479 samples) had sufficient vitamin D levels (25OHD ≥ 12.0 ng/mL). In addition to 25OHD and ALP, both TRACP-5b and sNTx were measured in 331 infants (418 samples), while 90 infants (105 samples) had only TRACP-5b measured and 101 infants (103 samples) had only sNTx measured. Statistical comparison of 104 subjects each in the vitamin D deficiency and sufficiency groups after matching for the background characteristics revealed that the vitamin D deficiency group had significantly higher levels of ALP and iPTH compared with the sufficiency group (P = <.0001, .0012, respectively). However, no significant differences were found in TRACP-5b and NTx levels between the 2 groups (P = .19, .08, respectively). Our findings suggest discordant responses between bone formation and resorption markers in subclinical vitamin D deficiency during infancy.