P300是与事件相关的电位,作为评估认知的客观工具进行探索。本研究旨在利用脑电图(EEG)研究单侧HS的TLE患者的听觉和视觉P300的特征,并研究其与认知的相关性。
这是一项横断面病例对照研究,在30例单侧海马硬化伴难治性癫痫患者的P300特征与15岁相比,性别-,和教育年龄匹配的健康对照(M:F-10:5,平均年龄-28±4.76岁)。在患者中,15属于右HS组(M:F-9:6,发病年龄-12.92±10.22岁,癫痫的持续时间为16.67±9.38年),左HS组15岁(M:F-8:7,发病年龄为10.62±7.18岁,癫痫的持续时间-15.53±10.14年)。所有受试者都接受了基于EEG的听觉和视觉古怪任务以及认知评估。在EEG中预测P300延迟(以毫秒为单位)以及振幅(以微伏为单位),并且与认知评分相关。使用CLARA算法执行P300的源定位。
控制中的听觉P300延迟,右HS,左HS分别为323.93±40.28、351.06±47.23和328.80±36.03(p=0.18),其幅度分别为2.3040±1.46、2.77±1.19和2.68±1.78(p=0.48)。控件中的VisualP300延迟,右HS,左HS分别为365.87±47.37、359.67±64.45和376.00±60.06(p=0.51),其幅度分别为3.93±2.28、2.09±1.45和3.56±1.74(p=0.014)。Further,与对照组相比,患者组的认知评分较低(p<0.05)。
与对照相比,右HS患者在视觉P300上记录的振幅较小,在认知测试中记录的评分较低.P300和认知参数表现出不同的关系。P300可能是评估TLE患者认知功能的补充客观工具。
P300 is an event-related potential, being explored as an objective tool to assess cognition. This study aimed to investigate the characteristics of auditory and visual P300 in patients with TLE having unilateral HS using electroencephalography (EEG) and to study its correlation with cognition.
This is a cross-sectional
case-control study, where
P300 characteristics in thirty patients with unilateral hippocampal sclerosis with refractory epilepsy were compared with fifteen age-, gender-, and years of education-matched healthy controls (M: F-10:5, mean age-28 ± 4.76 years). Among patients, 15 belonged to the right HS group (M: F-9:6, age at onset-12.92 ± 10.22 years, duration of epilepsy-16.67 ± 9.38 years) and 15 to the left HS group (M: F-8:7, age at onset-10.62 ± 7.18 years, duration of epilepsy-15.53 ± 10.14 years). All subjects underwent EEG-based auditory and visual oddball tasks and cognitive assessment. The P300 latencies (in milliseconds) as well as amplitudes (in microvolts) were predicted in EEG and were correlated with cognitive scores. Source localization of
P300 was performed with the CLARA algorithm.
The auditory P300 latencies in controls, right HS, and left HS were 323.93 ± 40.28, 351.06 ± 47.23, and 328.80 ± 36.03, respectively (p = 0.18) and its amplitudes were 2.3040 ± 1.46, 2.77 ± 1.19, and 2.68 ± 1.78, respectively (p = 0.48). Visual P300 latencies in controls, right HS, and left HS were 365.87 ± 47.37, 359.67 ± 64.45, and 376.00 ± 60.06, respectively (p = 0.51) and its amplitudes were 3.93 ± 2.28, 2.09 ± 1.45, and 3.56 ± 1.74, respectively (p = 0.014). Further, when compared to the control group the cognitive scores were lower in the patient group (p < 0.05).
In comparison to the controls, patients with right HS recorded lesser amplitude on visual P300 and lower scores on cognitive tests.
P300 and cognitive parameters exhibited varied relationship.
P300 could be a complementary objective tool to assess cognition in patients with TLE.