未经证实:使用臭氧治疗来管理COVID-19患者在先前的研究中一直伴随着相互矛盾的结果。因此,我们旨在广泛评估臭氧作为COVID-19患者辅助治疗的效果.
未经授权:PubMed,Scopus,WebofScience,科克伦,ProQuest,Springer,和Sage期刊进行了系统搜索,直到2022年4月。死亡率,入住ICU,住院时间,PCR阴性,肺,肾,和肝功能,以及炎症和血液系统被合并,以比较臭氧作为邻近治疗(OZ)和标准治疗(ST)的疗效.使用随机/固定模型进行分析,分组分析,漏斗图,使用综合荟萃分析(CMA)软件2.0版进行敏感性分析。
UNASSIGNED:分析了4项随机临床试验(RCT)和4项病例对照研究的结果,共371例COVID-19阳性患者。OZ组患者住院时间较短(P>0.05),ICU入院率较低(P>0.05),死亡率低于ST组(P<0.05)。治疗后,PCR检测阴性的COVID-19患者比ST组多41%(P<0.05)。两组血清肌酐和尿素水平均未改变(P>0.05)。此外,除了白蛋白血清水平,OZ组明显下降,血清胆红素,ALT,两组AST均未改变(P>0.05)。两组均未显示血C反应蛋白水平降低(P>0.05),但OZ组血清LDH水平显着变化(P<0.05)。与D-二聚体和WBC血清水平不同(P>0.05),OZ组血小板水平升高(P<0.05)。两组均未出现副作用。
UNASSIGNED:臭氧治疗对PCR检测和LDH血清水平显着有效,以及基于总体估计的死亡率。关于住院时间和ICU入院时间,尽管结果微不足道,它们的效应大小在临床上是显著的.需要更多的RCT研究来显示臭氧疗法对其他研究变量的功效。
UNASSIGNED: Using ozone therapy to manage COVID-19 patients has been accompanied by conflicting results in prior studies. Therefore, we aimed to widely assess the effects of ozone as adjuvant therapy in COVID-19 patients.
UNASSIGNED: PubMed, Scopus, Web of Science, Cochrane, ProQuest, Springer, and Sage journals were searched systematically until April 2022. Mortality rate, ICU admission, hospital-length stay, negative PCR, pulmonary, renal, and hepatic functions, as well as inflammatory and blood systems were pooled to compare the efficacy of ozone as adjacent therapy (OZ) and standard treatment (ST). Analyses were run with the random/fixed models, sub-group analysis, funnel plot, and sensitivity analysis using comprehensive meta-analysis (CMA) software version 2.0.
UNASSIGNED: The results of four randomized clinical trials (RCTs) and four case-control studies with a total of 371 COVID-19 positive patients were analyzed. The OZ group patients had a shorter length of hospital stay (P > 0.05), lower ICU admissions (P > 0.05), and lower mortality rates (P < 0.05) than the ST group cases. After treatment, 41% more COVID-19 patients had negative PCR tests than the ST group (P < 0.05). Serum creatinine and urea levels were not modified in either group (P > 0.05). Moreover, except for albumin serum levels, which decreased significantly in the OZ group, serum bilirubin, ALT, and AST were not modified in either group (P > 0.05). Both arms did not show a decrease in C-reactive protein blood levels (P > 0.05), but the OZ group showed a significant modification in LDH serum levels (P < 0.05). Unlike the d-dimer and WBC serum levels (P > 0.05), platelet levels were increased in the OZ group (P < 0.05). No negative side effects were demonstrated in either group.
UNASSIGNED: Ozone therapy was effective significantly on PCR test and LDH serum levels, as well as mortality based on overall estimation. Concerning the length of hospital stay and ICU admissions, although the results were insignificant, their effect sizes were notable clinically. More RCT studies are needed to show the efficacy of ozone therapy on other studied variables.