尽管门诊肠外抗生素治疗(OPAT)可以是治疗感染的好方法,缺乏有关便携式弹性输液装置中抗生素稳定性的数据限制了其安全性,适当,有效使用。这项工作的目的是完成对发表的有关弹性输液装置中抗生素稳定性的文章的系统同行评审分析,这些文章提供了支持其在OPAT中使用的证据。
根据PRISMA指南于2021年1月进行了系统评价,以确定有关便携式弹性输液装置中抗生素稳定性的已发表文章。使用的数据库是PubMed,Embase,WebofScience,还有一个Cochrane数据库.总共发现了1,615项原始研究和会议通讯。标题之后,abstract,和全文回顾,33篇文章符合纳入标准。获得的数据包括关于30种不同抗生素的稳定性的信息。据我们所知,这是第一篇综述,总结了有关便携式弹性输液装置中抗生素稳定性的现有公开数据。结果突出了某些抗生素在溶液中的稳定性差以及所包括研究中的实验室条件的可变性。
本系统综述可作为参与使用便携式弹性输液设备提供OPAT的医疗保健专业人员的有用资源。然而,应进行进一步的稳定性研究,特别是模拟真实时间和温度条件的高质量研究。
OBJECTIVE: Although outpatient parenteral antibiotic therapy (OPAT) can be a good approach to treatment of infections, a lack of data regarding antibiotic stability in portable elastomeric infusion devices restricts its safe, appropriate, and effective use. The objective of this work was to complete a systematic peer-reviewed analysis of published articles about antibiotic stability in elastomeric infusion devices that provide evidence supporting their use in OPAT.
CONCLUSIONS: A systematic
review following PRISMA guidelines was conducted in January 2021 to identify published articles about antibiotic stability in portable elastomeric infusion devices. The databases used were PubMed, Embase, Web of Science, and a Cochrane database. A total of 1,615 original studies and conference communications were found. After title, abstract, and full-text
review, 33 articles met the inclusion criteria. The data obtained included information about the stability of 30 different antibiotics. To our knowledge, this is the first
review to summarize the available published data on the stability of antibiotics in portable elastomeric infusion devices. The results highlight the poor stability of some antibiotics in solution and the variability of the laboratory conditions in the included studies.
CONCLUSIONS: This systematic
review can serve as a useful resource for healthcare professionals involved in providing OPAT using portable elastomeric infusion devices. However, further stability studies should be performed, especially high-quality studies simulating real-life time and temperature conditions.