小叶毛细血管瘤(LCH-PG)是一种化脓性肉芽肿,其特征是增生的血管类似于常规肉芽组织。经常看到与向内生长的脚趾甲相关的肉芽组织。尽管这两个实体之间有着密切的关系,LCH-PG在临床上表现出不同的行为,如快速增长和频繁复发。目前,目前尚不清楚不同的病因因素是如何导致实体之间差异的形成。我们介绍了一例26岁男性的大型LCH-PG与慢性甲癣有关。组织病理学特征包括广泛的溃疡征象,角化过度,和斑片状表皮棘皮病,存在纤维间隔,溃疡区下方有小叶区。基质的存在具有明显的血管增生,壁增厚和混合型炎症变化也是特征性的。在甲癣的晚期阶段,正如这里所介绍的,常规肉芽组织或化脓性肉芽肿在临床上难以与其他良性或恶性肿瘤区分。组织学检查是强制性的,切除活检可以提供明确的诊断。
Lobular capillary hemangioma (LCH-PG) is a type of pyogenic granuloma characterized by proliferating blood vessels that resemble conventional granulation tissue. Granulation tissue is very often seen in association with ingrown toenails. Despite the close relationship between both entities, LCH-PG shows clinically different behaviors, such as rapid growth and frequent recurrence. Currently, it is unknown exactly how the different etiological factors contribute to the formation of differences between entities. We present a
case of a large LCH-PG associated with chronic
onychocryptosis in a 26-year-old man. Histopathological features included extensive signs of ulceration, hyperkeratosis, and patchy epidermal acanthosis with the presence of fibrous septa with lobular areas beneath the ulcerative area. The presence of stroma with a marked proliferation of blood vessels with wall thickening and mixed-type inflammatory changes was also characteristic. In advanced stages of
onychocryptosis, as presented here, conventional granulation tissue or pyogenic granuloma can be clinically difficult to distinguish from other benign or malignant neoplasms. Histological examination is mandatory, and excisional biopsy can provide a definitive diagnosis.