■随着与代谢功能障碍相关的脂肪肝的全球患病率上升,这种常见的肝脏疾病与慢性肾脏病(CKD)之间的关联越来越明显.2020年,提出了更具包容性的术语代谢功能障碍相关脂肪性肝病(MAFLD)取代术语非酒精性脂肪性肝病(NAFLD)。观察到的MAFLD和CKD之间的关联以及我们对CKD可能是潜在代谢功能障碍的结果的理解支持了以下观点:与没有MAFLD的人相比,患有MAFLD的人患CKD的风险更高。然而,到目前为止,对于MAFLD患者的CKD没有适当的指导。此外,在肾内科中,很少有人关注MAFLD和CKD之间的联系.
■使用基于Delphi的方法,一个由来自26个国家的50名国际专家组成的多学科小组就一些关于MAFLD和CKD之间联系的公开研究问题达成了共识.
■这份基于德尔菲的共识声明为流行病学提供了指导,机制,MAFLD和CKD的管理和治疗,以及MAFLD的严重程度与CKD风险之间的关系,建立了早期预防和管理这两种常见和相互关联的疾病的框架。
UNASSIGNED: With the rising global prevalence of fatty liver disease related to metabolic dysfunction, the association of this common liver condition with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the term non-alcoholic fatty liver disease (NAFLD). The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD. However, to date, there is no appropriate guidance on CKD in individuals with MAFLD. Furthermore, there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.
UNASSIGNED: Using a Delphi-based approach, a multidisciplinary panel of 50 international experts from 26 countries reached a
consensus on some of the open research questions regarding the link between MAFLD and CKD.
UNASSIGNED: This Delphi-based
consensus statement provided guidance on the epidemiology, mechanisms, management and treatment of MAFLD and CKD, as well as the relationship between the severity of MAFLD and risk of CKD, which establish a framework for the early prevention and management of these two common and interconnected diseases.