■脊髓损伤(SCI)患者在损伤后数年内可发展为尿路结石(UTSs),这在头几个月尤其常见。然而,台湾缺乏SCI的相关流行病学研究和最新流行病学数据.
■为了估计SCI和SCI引起的UTS发生率和创伤严重程度,神经功能缺损,台湾SCI诱导的UTS患者的损伤部位。
■回顾性队列研究。患者样本:台湾国家健康保险研究数据库(NHIRD)数据和死亡数据,来自卫生和福利数据科学中心(HWDC),从2005-2015年收集了13,977名年龄>18岁的SCI患者。
■累积发病率(CI),入射密度(ID),相对比率(RR),赔率比(OR),并测量了风险比(HR)。
■通过使用Cox回归,我们评估了SCI患者的UTS风险。
■尽管标准SCI发病率呈逐年下降趋势,年平均发病率保持在百万分之六。大多数(65.7%)的患者是男性。男性SCI发病率是女性的1.98倍。最常见的损伤部位是颈椎(63.8%);男性的发病率是女性的2.83倍。大多数(76.1%)患者有创伤性SCI(TSCI),TSCI和非TSCI的标准化发生率分别为45.9和14.4百万分之一,分别。46.1%的患者患有严重SCI(RISS≥16)。在11年的随访期内,10.4%的患者发生UTSs,标准化发病率为每100人年2.39,男性的UTS风险是女性的1.56倍。年龄45-65岁,多个站点的SCIs,和神经功能缺损(例如截瘫)被认为是UTS的危险因素。最后,UTS发病主要发生在SCI后的第一年。
■SCI患者的UTS风险受年龄影响,性别,损伤部位,和截瘫,但不是由其他神经缺陷导致的瘫痪。尽管SCI发病率每年都在下降,严重的SCI仍然是一个重大问题。因此,继续降低SCI发生率和加强SCI患者的尿路管理对于减少UTS的发生及其对健康的影响至关重要。
UNASSIGNED: Patients with spinal cord injury (SCI) can develop urinary tract stones (UTSs) up to years after the injury, which is especially common in the first few months. However, relevant epidemiological studies and up-to-date epidemiological data for SCI in Taiwan are lacking.
UNASSIGNED: To estimate SCI and SCI-induced UTS incidence and trauma severity, neurological deficits, and injury site in patients with SCI-induced UTSs in Taiwan.
UNASSIGNED: Retrospective cohort study.Patient sample: Taiwan National Health Insurance Research Database (NHIRD) data and death data from the Department of Health and Welfare Data Science Center (HWDC) collected over 2005-2015 from 13,977 patients with SCI aged >18 years.
UNASSIGNED: Cumulative incidence (CI), incidence density (ID), relative ratios (RRs), odds ratios (ORs), and hazard ratios (HRs) were measured.
UNASSIGNED: By using Cox regression, we assessed UTS risk in patients with SCI.
UNASSIGNED: Although standardized SCI incidence demonstrated a decreasing trend annually, the average annual incidence remained at 60.4 per million. Most (65.7%) of the included patients were men. SCI incidence was 1.98 times higher in men than in women. The most common injury site was the cervical spine (63.8%); the incidence at this site was 2.83 times higher in men than in women. Most (76.1%) of the patients had traumatic SCI (TSCI), and the standardized incidence of TSCI and non-TSCI was 45.9 and 14.4 per million, respectively. 46.1% of the patients had severe SCI (RISS ≥ 16). Over the 11-year follow-up period, UTSs occurred in 10.4% of the patients, with a standardized incidence of 2.39 per 100 person-years, and UTS risk was 1.56 times higher in men than in women. Age of 45-65 years, SCIs at multiple sites, and neurological deficits (e.g. paraplegia) were noted to be UTS risk factors. Finally, UTS onset mainly occurred in the first year after SCI.
UNASSIGNED: The risk of UTS among patients with SCI is influenced by age, sex, injury site, and paraplegia but not by paralysis resulting from other neurological deficits. Even though SCI incidence is declining annually, severe SCI remains a significant issue. Therefore, continuing to reduce SCI incidence and strengthening urinary tract management in patients with SCI are essential for reducing UTS occurrence and their impact on health.