哺乳动物小脑的发育是由细胞自主程序和诱导性环境影响协调的。这里,我们描述了小脑个体发育的主要过程,强调发展祖细胞所使用的神经源策略,涉及细胞命运规范的遗传程序,结构组织的渐进变化,以及一些与小脑发育障碍相关的众所周知的异常。
The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.