背景:塞洛西亚cristataL.(C.cristata)是一种在中国广泛使用的草药,已被用作药物超过1000年。该草药已在临床上用于治疗各种类型的出血性疾病,包括子宫出血,metrostaxis,和白血病,胃肠道感染。
目的:这篇综述提供了一个全面的分析,包括它的植物学,传统应用,植物化学,药理学,安全,和质量控制。此外,它深入研究了当代关于C.cristata的研究的普遍挑战和局限性,从而为该领域的未来调查提供有价值的见解。
方法:研究数据来自权威来源,包括中国药典,中国植物区系,以及各种互联网数据库,如WebofScience,CASCiFinder,PubMed,科学直接,和CNKI,以及许多古代中草药经典。
结果:C.cristata的临床应用证明了其治疗功能失调性子宫出血的疗效,阴道炎,和盆腔炎.目前,已分离出77种化合物,包括类黄酮,三萜类,类固醇,有机酸,苯丙素类化合物,和生物碱,黄酮类化合物和三萜类化合物是主要的生物活性成分。药理学研究揭示了其多样化的生物活性,比如止血,反滴虫,抗菌,抗病毒,镇痛药,免疫调节,抗炎,抗癌,保肝,和抗氧化作用。利用网络药理学,研究人员已经开始对化学成分之间的相互作用进行初步调查,分子靶标和病理状况。
结论:C.cristata显示出用于止血的巨大潜力,抗炎,和抗菌治疗。现代研究揭示了其多样化的化学成分和药理活性,使其对进一步研究非常有价值。同时,有必要找到C.crista的特征成分并建立更好的质量控制标准,以更好地发掘其治疗潜力。
BACKGROUND: Celosia cristata L. (C. cristata) is a widely used herb in China and has been used as a medicine for more than 1000 years. The herb has been clinically employed to treat various types of bleeding disorders including metrorrhagia, metrostaxis, and leukorrheal diseases, gastrointestinal infections.
OBJECTIVE: This
review provides a comprehensive analysis of C. cristata, encompassing its botany, traditional applications, phytochemistry, pharmacology, safety, and quality control. Additionally, it delves into the prevailing challenges and limitations with contemporary research concerning C. cristata, thus furnishing valuable insights for future investigations in this domain.
METHODS: Research data were gathered from authoritative sources including the Pharmacopoeia of China, the Flora of China, as well as various internet databases such as Web of Science, CAS CiFinder, PubMed, Science Direct, and CNKI, along with numerous ancient classics on Chinese herbal medicine.
RESULTS: Clinical applications of C. cristata demonstrate its efficacy in treating dysfunctional uterine bleeding, vaginitis, and pelvic inflammatory disease. Presently, seventy-seven compounds have been isolated, including flavonoids, triterpenoids, steroids, organic acids, phenylpropanoids, and alkaloids, with flavonoids and triterpenoids emerging as the primary bioactive constituents. Pharmacological studies reveal its diverse biological activities, such as haemostatic, antitrichomonal, antibacterial, antiviral, analgesic, immunoregulatory, anti-inflammatory, anticancer, hepatoprotective, and antioxidant effects. Leveraging network pharmacology, researchers have embarked on preliminary inquiries into the interplay among chemical constituents, molecular targets and pathological conditions.
CONCLUSIONS: C. cristata shows significant potential for use in hemostasis, anti-inflammatory, and antimicrobial treatments. Modern research has revealed its diverse chemical composition and pharmacological activities, making it highly valuable for further study. At the same time, it is necessary to find the characteristic components of C. cristata and establish better quality control standards to better explore its therapeutic potential.