背景:1998年,Kajander和Ciftçioñlu描述了未知的细胞培养污染物。这些污染物最初被称为纳米细菌,后来被称为钙化纳米颗粒(CNP)。它们的确切性质尚不清楚且有争议。CNP具有独特和不寻常的特征,这就排除了将它们置于任何已建立的生命进化分支中的可能性。
目的:本系统评价的目的是评估1998年以来关于CNPs的公开数据,特别是与牙科疾病有关的数据。
方法:进行了国家医学图书馆(PubMed)和摄影仪器工程师协会(SPIE)的电子和手动搜索。使用纳米细菌和钙化纳米颗粒作为关键词。搜索产生了135篇全长论文。根据审查标准对标题和摘要进行进一步筛选,得出了43篇符合研究目标的论文。
结论:评论显示纳米细菌的存在仍然存在争议。一些研究人员描述了CNPs可能参与牙髓和唾液腺钙化,以及CNP在治疗破裂和/或侵蚀牙齿中的可能治疗用途。
BACKGROUND: Unknown cell-culture contaminants were described by Kajander and Ciftçioğlu in 1998. These contaminants were called
nanobacteria initially and later calcifying nanoparticles (CNPs). Their exact nature is unclear and controversial. CNPs have unique and unusual characteristics, which preclude placing them into any established evolutionary branch of life.
OBJECTIVE: The aim of this systematic
review was to assess published data concerning CNPs since 1998 in general and in relation to dental diseases in particular.
METHODS: The National Library of Medicine (PubMed) and Society of Photographic Instrumentation Engineers (SPIE) electronic and manual searches were conducted.
Nanobacteria and calcifying nanoparticles were used as keywords. The search yielded 135 full-length papers. Further screening of the titles and abstracts that followed the
review criteria resulted in 43 papers that met the study aim.
CONCLUSIONS: The
review showed that the existence of
nanobacteria is still controversial. Some investigators have described a possible involvement of CNPs in pulpal and salivary gland calcifications, as well as the possible therapeutic use of CNPs in the treatment of cracked and/or eroded teeth.