现有文献中广泛报道了植入物相关淋巴瘤,如间变性大细胞淋巴瘤,但乳腺植入物相关鳞状细胞癌(BIA-SCC)自1992年首例病例以来受到的学术关注有限.因此,这项研究旨在对乳房植入物与BIA-SCC之间的未充分挖掘关联进行定性综合.利用PubMed进行了系统评价,WebofScience,和Cochrane数据库来识别所有目前报告的BIA-SCC病例。此外,我们进行了文献综述,以确定可能导致BIA-SCC的潜在生化机制.使用NIH质量评估工具对研究进行了质量审查。从最初的246篇论文中,11符合纳入质量标准,共检查14名年龄在40至81岁之间的患者。BIA-SCC在各种各样的植入物中发现,包括那些光滑和有纹理的表面,以及那些充满盐水和硅胶的。这种情况显着表现出积极的临床进展倾向,诊断后6个月内的死亡率约为21.4%。我们的文献综述显示,慢性炎症,由病原体和植入物等各种外部因素驱动,可以通过表观遗传修饰和免疫系统改变引发致癌作用。这包括外来体和巨噬细胞极化的影响,展示BIA-SCC发病机制的潜在途径。该研究强调了对BIA-SCC进行进一步调查的迫切需要,一个迄今为止在学术领域没有得到充分解决的主题。这就需要进行早期筛查和干预以改善术后结果。虽然审查受限于对病例报告和系列的依赖,它为未来的研究工作提供了宝贵的参考。
There is extensive coverage in the existing literature on implant-associated lymphomas like anaplastic large-cell lymphoma, but breast implant-associated squamous cell carcinoma (BIA-SCC) has received limited scholarly attention since its first
case in 1992. Thus, this study aims to conduct a qualitative synthesis focused on the underexplored association between breast implants and BIA-SCC. A systematic review was conducted utilizing the PubMed, Web of Science, and Cochrane databases to identify all currently reported cases of BIA-SCC. Additionally, a literature review was performed to identify potential biochemical mechanisms that could lead to BIA-SCC. Studies were vetted for quality using the NIH quality assessment tool. From an initial pool of 246 papers, 11 met the quality criteria for inclusion, examining a total of 14 patients aged between 40 and 81 years. BIA-SCC was found in a diverse range of implants, including those with smooth and textured surfaces, as well as those filled with saline and silicone. The condition notably manifested a proclivity for aggressive clinical progression, as evidenced by a mortality rate approximating 21.4% within a post-diagnostic interval of six months. Our literature review reveals that chronic inflammation, driven by various external factors such as pathogens and implants, can initiate carcinogenesis through epigenetic modifications and immune system alterations. This includes effects from exosomes and macrophage polarization, showcasing potential pathways for the pathogenesis of BIA-SCC. The study highlights the pressing need for further investigation into BIA-SCC, a subject hitherto inadequately addressed in the academic sphere. This necessitates the urgency for early screening and intervention to improve postoperative outcomes. While the review is confined by its reliance on
case reports and series, it serves as a valuable reference for future research endeavors.