背景:女性最常见的抱怨之一是痛经。几项研究调查了药用植物对原发性痛经的治疗效果。
目的:本系统综述和荟萃分析研究了与非甾体类抗炎药如甲芬那酸相比,茴香对原发性痛经疼痛的影响。
方法:PubMed,EMBASE,EBSCOWebofScience,Scopus,科克伦图书馆,Cochrane中央对照试验登记册(中央),科学直接,ProQuest,ISIWebofScience,谷歌学者,马吉兰,SID,伊朗Medex,和伊朗医生被搜索到2019年1月。临床试验质量评价采用Jadad评分系统。完全正确,在荟萃分析中输入了12项研究。计算I2以确定异质性。应用固定效应和/或随机效应模型。
结果:这些试验的荟萃分析显示,与安慰剂相比,普通F.vulgare的摄入量显着降低了痛经的强度(SMD-0.632;CI:-0.827至-0.436;p<0.001;异质性p=0.807;I2=0%;固定效应模型;七篇文章)。然而,甲芬那酸与寻常型弧菌的效果无差异(SMD=-0.214;CI:-0.446~0.017;p=0.07;异质性p=0.58;I2=0%;固定效应模型;6项试验).
结论:普通F.vulgare可减轻痛经。关于与NSAIDs相同的作用,强烈建议患有痛经的女性,特别是那些倾向于草药的女性。
BACKGROUND: One of the most common complaints for women is dysmenorrhea. Several studies investigated the treatment effects of medicinal plants on primary dysmenorrhea.
OBJECTIVE: This systematic
review and meta-analysis investigates the effect of Foeniculum vulgare (Fennel) on pain in primary dysmenorrhea in comparison to non-steroidal anti-inflammatory drugs such as mefenamic acid.
METHODS: PubMed, EMBASE, EBSCO Web of Science, Scopus, Cochrane library, Cochrane Central Register of Controlled Trials (CENTRAL), Science Direct, ProQuest, ISI Web of Science, Google Scholar, Magiran, SID, Iran Medex, and Irandoc were searched up to January 2019. Quality assessment of clinical trials was conducted using Jadad scoring system. Totally, 12 studies were entered in the meta-analysis. I 2 was calculated to determine heterogeneity. Fixed effects and/or random effects models were applied.
RESULTS: Meta-analysis of these trials showed that F. vulgare intake decreased significantly the intensity of dysmenorrhea compared to the placebo (SMD -0.632; CI: -0.827 to -0.436; p<0.001; heterogeneity p=0.807; I 2=0%; fixed effect model; seven articles). However, the effect of Mefenamic acid with F. vulgare was not different from each other (SMD=-0.214; CI: -0.446 to 0.017; p=0.07; heterogeneity p=0.58; I 2=0%; fixed effect model; six trials).
CONCLUSIONS: The F. vulgare alleviates dysmenorrhea. Regarding the same effect of F. vulgare with NSAIDs, it is highly recommend to the women suffered from dysmenorrhea specifically the ones who have high tendency toward herbal medicine.