■糖皮质激素受体(GCR)在不同大脑区域的广泛分布,以及在重度抑郁症(MDD)中下丘脑-垂体-肾上腺(HPA)轴的破坏以及GCR和HPA之间的串扰提出了GC受体基因的遗传变异是MDD的潜在贡献者。在GCR多态性中,建议rs41423247、rs6195和rs6189/rs6190参与MDD。
■我们在一项病例对照研究中调查了rs41423247,rs6195和rs6189/rs6190与MDD之间的关联。100名MDD患者和100名健康个体被纳入这项研究。使用PCR-RFLP在提取的DNA中确定rs41423247,rs6195和rs6189/rs6190的遗传变异。
■rs41423247的杂合子和突变携带者的患病率在病例中显著高于对照组1.9倍(P=0.033;OR;95CI=1.9;1.1-3.3)。此外,突变(G)等位基因的携带者在MDD组中的患病率增加了1.8倍(P=0.013;OR;95CI=1.8;1.1-2.8)。
■rs41423247的特定载体可能更容易发生MDD。这支持GCR参与MDD病理生理学的假设。
UNASSIGNED: Extensive distribution of glucocorticoid receptors (GCRs) in different brain areas along with disruption of hypothalamic-pituitary-adrenal (HPA) axis in
major depressive disorder (MDD) and the cross talk between GCRs and HPA proposes genetic variants of GC receptor genes as potential contributors in MDD. Among the GCR polymorphisms, rs41423247, rs6195 and rs6189/rs6190 are suggested to be involved in MDD.
UNASSIGNED: We investigated the association between rs41423247, rs6195 and rs6189/rs6190 and MDD in a
case-control study. One hundred MDD patients along with 100 healthy individuals were enrolled in this study. genetic variants of rs41423247, rs6195 and rs6189/rs6190 were determined in extracted DNAs using PCR-RFLP.
UNASSIGNED: The prevalence of heterozygote and mutant carriers of rs41423247 were significantly and by 1.9 fold greater in cases versus controls (P=0.033; OR; 95%CI=1.9; 1.1-3.3). Moreover, carriers of the mutant (G) allele were by 1.8 fold more prevalent in MDD group (P=0.013; OR;95%CI=1.8; 1.1-2.8).
UNASSIGNED: Specific carriers of rs41423247 might be more susceptible to developing MDD. This supports the hypothesis of the involvement of GCRs in pathophysiology of MDD.