背景:植物是可变数量的有价值的次级代谢产物的储存库,具有生药学和药理学意义,有可能在未来成为超级药物。这些代谢物的体内生产受到生物和非生物胁迫的影响,导致各种植物化学物质及其衍生物的持续积累,可用于设计和开发未来的潜在药物。本研究的目的是回顾医学上重要的次生代谢产物的存在以及探索不足的杂草植物Hyptissuaveolens(L.)Poit。,探索该植物开发和设计未来药物的潜力。
■属于唇形科的Hyptissuaveolens是重要的药用植物化学物质的丰富来源,如精油,单宁,皂苷,酚类物质,黄酮类化合物,萜类化合物,生物碱,和固醇。这些化合物中的一种或多种具有抗氧化作用,抗炎,抗痉挛,防腐剂,抗癌,抗溃疡,抗菌,抗菌,抗病毒,抗真菌药,抗糖尿病,抗生育,发汗症,反皮肤,anticatarrhal,抗风湿,抗溃疡,胃保护,免疫调节,镇痛药,和抗病毒活性。
结论:菌泡病含有独特的萜类代谢产物,如菌泡酸,舒韦洛尔,硫酸甲酯,β-谷甾醇,熊果酸,和酚类化合物,如芳香酸,有潜力替代传统药物作为抗耐药和新出现的细菌和病毒病原体的治疗剂的罗莎二酸甲酯。五环三萜类,据报道,熊果酸对导致目前COVID-19大流行的SARS-CoV2和HIV病毒具有有效的抗病毒反应,迄今为止,尚无有效的疫苗。熊果酸具有调节主要蛋白酶(Mpro)活性的能力,这对于病毒复制和颗粒组装所需的SARS-CoV2复制酶-转录酶机制的加工至关重要。
BACKGROUND: Plants are the repository of variable number of valuable secondary metabolites that bears pharmacognostic and pharmacological implications having potentiality to emerge as super drugs in future. In-vivo production of these metabolites is influenced by the biotic and abiotic stresses resulting in continuous accumulation of diverse phytochemicals and their derivatives that can be useful in designing and developing potential drugs for future. The aim of the present study is to
review the existence of medicinally important secondary metabolites and possible pharmacological and pharmacognostic importance of under-explored weed plant species Hyptis suaveolens (L.) Poit., to explore the potentiality of the plant for developing and designing the drugs for future.
UNASSIGNED: Hyptis suaveolens belonging to family Lamiaceae is the rich source of medicinally important phytochemicals like essential oils, tannins, saponins, phenols, flavonoids, terpenoids, alkaloids, and sterols. One or many of these compounds have antioxidative, anti-inflammatory, antispasmodic, anti-septic, anti-cancer, anti-ulcer, antimicrobial, antibacterial, antiviral, antifungal, anti-diabetic, anti-fertility, diaphoretics, anticutaneous, anticatarrhal, antirheumatic, anti-ulcer, gastroprotective, immunomodulatory, analgesic, and antiviral activity.
CONCLUSIONS: Hyptis suaveolens contains unique terpenoid metabolites like suaveolic acid, suaveolol, methyl suaveolate, beta-sitosterol, ursolic acid, and phenolic compound like rosamarinic acid, methyl rosamarinate that have potentiality to substitute the traditional drugs as therapeutic agent against the resistant and newly emerged bacterial and viral pathogens. Pentacyclic triterpenoid, ursolic acid have been reported to have effective antiviral response against the SARS-CoV2 responsible for the present COVID-19 pandemic and HIV virus for which no effective vaccines are available till date. Ursolic acid has the ability to modulate the activity of main protease (Mpro) that is essential for processing of SARS-CoV2 replicase-transcriptase machinery needed for viral replication and particle assembly.