lysis of adhesions

粘连溶解
  • 文章类型: Review
    背景:当包皮粘附到龟头时,会发生阴蒂粘连。在高达22%的寻求性功能障碍评估的女性中发现了这些粘连。阴蒂粘连的病因仍不清楚。迄今为止发表的关于阴蒂粘连的表现和管理的研究是相对较新的,并为未来的研究提出了问题。
    目的:我们试图提供有关患病率的现有知识背景,介绍,病因学,相关条件,以及阴蒂粘连的管理,并确定未来研究的领域。
    方法:对研究阴蒂粘连的研究进行了文献综述。
    结果:与慢性阴蒂瘢痕形成相关的病症似乎在阴蒂粘连的发展中起作用。症状包括阴蒂疼痛(阴蒂痛),不适,超敏反应,敏感性低下,唤醒困难,消音或没有高潮。并发症包括炎症,感染,以及角蛋白珍珠和涂片假性囊肿的发展。有手术和非手术干预措施来管理阴蒂粘连。此外,保守和/或术后管理可以包括局部用药.尽管许多关于阴蒂粘连的研究仅限于硬化性苔藓(LS)患者,阴蒂粘连并不局限于该人群。
    结论:未来研究的领域包括阴蒂粘连的病因;这些知识对于改善预防和管理至关重要。此外,在以前的研究中,我们指导患者应用各种外用药物,并手动收回包皮以进行保守治疗或溶解后护理.然而,这些干预措施的疗效尚未得到研究.已经描述了手术和非手术溶解程序,用于治疗疼痛以及唤醒和性高潮的困难,这是导致与阴蒂粘连相关的性功能障碍的原因。尽管以前的研究已经评估了疗效和患者满意度,其中许多研究仅限于小样本量,并且仅针对LS患者.未来的研究需要为阴蒂粘连的管理提供标准的护理。
    Clitoral adhesions occur when the prepuce adheres to the glans. These adhesions have been found in up to 22% of women seeking evaluation for sexual dysfunction. The etiology of clitoral adhesions remains largely unclear. Studies published to date on the presentation and management of clitoral adhesions are relatively recent and raise questions for future research.
    We sought to provide a background of existing knowledge on the prevalence, presentation, etiology, associated conditions, and management of clitoral adhesions and to identify areas for future research.
    A review of literature was performed for studies that investigate clitoral adhesions.
    Conditions associated with chronic clitoral scarring appear to have a role in the development of clitoral adhesions. Symptoms include clitoral pain (clitorodynia), discomfort, hypersensitivity, hyposensitivity, difficulty with arousal, and muted or absent orgasm. Complications include inflammation, infection, and the development of keratin pearls and smegmatic pseudocysts. There are surgical and nonsurgical interventions to manage clitoral adhesions. Additionally, topical agents can be included in conservative and/or postprocedural management. Although many studies on clitoral adhesions are limited to patients with lichen sclerosus (LS), clitoral adhesions are not confined to this population.
    Areas for future research include etiologies of clitoral adhesion; such knowledge is imperative to improve prevention and management. Also, in previous studies, patients were instructed to apply various topical agents and manually retract the prepuce for conservative management or postlysis care. However, the efficacy of these interventions has not been investigated. Surgical and nonsurgical lysis procedures have been described for the management of pain and difficulties with arousal and orgasm that are causes of the sexual dysfunction associated with clitoral adhesion. Although previous studies have assessed efficacy and patient satisfaction, many of these studies were limited to small sample sizes and focused solely on patients with LS. Future studies are needed to inform a standard of care for the management of clitoral adhesions.
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  • 文章类型: Journal Article
    未经证实:术后膝关节纤维化是影响膝关节功能和步态的常见且潜在有害的并发症。一些队列研究报告了关节镜下粘连松解术(LOA)和麻醉下操作(MUA)后的良好结果。
    UNASSIGNED:回顾评估关节镜下LOA和MUA治疗膝关节术后关节纤维化的疗效和并发症的文献,并评估任何相关亚组是否与不同的临床表现和结果相关。
    未经评估:系统评价;证据水平,4.
    UNASSIGNED:本综述是根据PRISMA(系统评价和荟萃分析的首选报告项目)指南进行的。通过搜索美国国家医学图书馆(PubMed/MEDLINE),确定了从1990年1月1日至2021年4月1日发表的合格研究。EMBASE,和Cochrane数据库。该分析中包括的所有研究包括治疗患者的术前和术后运动范围测量。排除报告前交叉韧带重建后孤立性圈囊病变患者结局的研究。
    UNASSIGNED:纳入了由240名患者组成的8项研究。从索引手术到关节镜LOA和MUA的平均时间为8.4个月,术后平均随访31.2个月.所有研究均显示关节镜LOA后运动弧度有显着改善(41.6°)。临床上显著改善结果测量,包括国际膝关节文献委员会,西安大略省和麦克马斯特大学骨关节炎指数,膝关节损伤和骨关节炎结果评分,在所有适用研究的关节镜下LOA后报告。240名患者中,LOA和MUA后发生单一并发症(滑膜瘘),在没有干预的情况下解决。
    UNASSIGNED:本综述的结果表明,关节镜下LOA和MUA是膝关节术后关节纤维化的安全有效的治疗方法。
    UNASSIGNED: Postoperative knee arthrofibrosis is a common and potentially detrimental complication affecting knee function and gait. Several cohort studies have reported good outcomes after arthroscopic lysis of adhesions (LOA) with manipulation under anesthesia (MUA).
    UNASSIGNED: To review the literature assessing the efficacy and complications of arthroscopic LOA and MUA for postoperative arthrofibrosis of the knee and evaluate whether any relevant subgroups are associated with different clinical presentation and outcomes.
    UNASSIGNED: Systematic review; Level of evidence, 4.
    UNASSIGNED: This review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Eligible studies published from January 1, 1990, to April 1, 2021, were identified through a search of the US National Library of Medicine (PubMed/MEDLINE), EMBASE, and Cochrane databases. All studies included in this analysis included pre- and postoperative range of motion measurements for their treated patients. Studies reporting outcomes for patients with isolated cyclops lesions after anterior cruciate ligament reconstruction were excluded.
    UNASSIGNED: Eight studies comprising 240 patients were included. The mean time from index surgery to arthroscopic LOA and MUA was 8.4 months, and the mean postoperative follow-up was at 31.2 months. All studies demonstrated a significant improvement (41.6°) in arc of motion after arthroscopic LOA. Clinically significant improvements in outcome measures, including the International Knee Documentation Committee, Western Ontario and McMaster Universities Osteoarthritis Index, and Knee injury and Osteoarthritis Outcome Score, were reported after arthroscopic LOA across all applicable studies. Of 240 patients, a single complication (synovial fistula) occurred after LOA and MUA, which resolved without intervention.
    UNASSIGNED: The results of this review indicated that arthroscopic LOA and MUA is a safe and efficacious treatment for postoperative arthrofibrosis of the knee.
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