Acropialophora是在温带和热带地区发现的一种腐生真菌。该属由16种组成,与亚种A.fusisspora和A.levis需要最多的临床关注。Acropialophora是一种机会性病原体,临床表现广泛;真菌与真菌性角膜炎有关,肺部感染,脑脓肿.Acropialophora感染对于免疫功能低下的患者尤其令人担忧。通常表现为涉及播散性感染的更严重的病程,并且可能没有典型症状。早期诊断和治疗干预是成功的临床管理的关键。抗真菌治疗指南尚未建立,部分原因是缺乏记录在案的案例。需要积极使用抗真菌药物和长期治疗,特别是在免疫受损患者和全身受累患者中,由于潜在的发病率和死亡率。除了概述这种疾病的稀有性和流行病学,这篇综述概述了Acropialophora感染的诊断和临床治疗,以促进早期诊断和适当的干预措施。
Acrophialophora is a saprotrophic genus of fungi found in both temperate and tropical regions. The genus is comprised of 16 species, with the subspecies A. fusispora and A. levis necessitating the most clinical concern. Acrophialophora is an opportunistic pathogen with a broad range of clinical manifestations; the fungus has been implicated in cases of fungal keratitis, lung infection, and brain abscess. Acrophialophora infection is particularly of concern for immunocompromised patients, who often present with a more severe disease course involving disseminated infection and may not exhibit typical symptoms. Early diagnosis and therapeutic intervention are critical to the successful clinical management of Acrophialophora infection.
Guidelines for antifungal treatment have yet to be established, partially due to the lack of documented cases. Aggressive use of antifungal agents and long-term treatment is required, especially in immunocompromised patients and patients with systemic involvement, due to the potential for morbidity and mortality. In addition to outlining the rarity and epidemiology of the disease, this review provides an overview of the diagnosis and clinical management of Acrophialophora infection to facilitate an early diagnosis and appropriate interventions.