心血管疾病是全世界死亡的主要原因。它们是影响心血管系统的非传染性疾病,并且具有不同的病因,例如吸烟,脂质紊乱,糖尿病,压力,久坐的生活方式和遗传因素。迄今为止,lncRNAs与高血压等心血管疾病发展的易感性增加有关。急性心肌梗死,中风,心绞痛和心力衰竭。这样,lncRNAs正在成为预防和诊断心血管疾病的一个非常有希望的点。因此,这篇综述强调了关于lncRNAsANRIL的作用机制的最重要和最新的发现,H19和TUG1及其在这些病理中的临床相关性。这可能有助于心血管疾病的早期检测,以防止病理表型的建立。
Cardiovascular diseases are the leading cause of death worldwide. They are non-transmissible diseases that affect the cardiovascular system and have different etiologies such as smoking, lipid disorders, diabetes, stress, sedentary lifestyle and genetic factors. To date, lncRNAs have been associated with increased susceptibility to the development of cardiovascular diseases such as hypertension, acute myocardial infarction, stroke, angina and heart failure. In this way, lncRNAs are becoming a very promising point for the prevention and diagnosis of cardiovascular diseases. Therefore, this
review highlights the most important and recent discoveries about the mechanisms of action of the lncRNAs ANRIL, H19 and TUG1 and their clinical relevance in these pathologies. This may contribute to early detection of cardiovascular diseases in order to prevent the pathological phenotype from becoming established.