目的:COVID-19最近已成为对全球健康的严重威胁。这项研究检查了COVID-19患者的实验室检查,重点是肝酶。
方法:本回顾性研究,单中心研究是对ImamReza医院收治的COVID-19患者进行的,伊朗从2020年3月到2021年2月。实验室检查包括全血细胞计数,白细胞(WBC)计数,中性粒细胞/淋巴细胞比率(NLR),血小板/淋巴细胞比率(PLR),淋巴细胞/单核细胞比率,以及天冬氨酸转氨酶水平,丙氨酸氨基转移酶(ALT),和碱性磷酸酶。患者生存率是与实验室检查结果相关的结果指标之一。
结果:我们招募了77例COVID-19患者和63例健康对照。与对照组相比,COVID-19患者显示COVID-19ALT升高,WBC,中性粒细胞,NLR,和PLR,血小板计数和淋巴细胞减少。
结论:尽管AST水平升高,NLR,PLR,在COVID-19患者中发现LMR,它们与死亡率无关。鉴于其他组织中存在AST,SARS-CoV-2对肝脏的影响应谨慎解释。
OBJECTIVE: COVID-19 has recently emerged as a serious threat to global health. This study examined the laboratory investigations of patients with COVID-19, with an emphasis on liver enzymes.
METHODS: This retrospective, single-center study was performed on patients with COVID-19 who were admitted to Imam Reza Hospital, Iran from March 2020 to February 2021. Laboratory tests included a complete blood cell count, white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio, and levels of aspartate aminotransferase, alanine aminotransferase (ALT), and alkaline phosphatase. Patient survival was among the outcome measures investigated in association with laboratory findings.
RESULTS: We enrolled 77 patients with COVID-19 and 63 healthy controls. In comparison with the control group, patients with COVID-19 showed COVID-19 increased ALT, WBC, neutrophils, NLR, and PLR, and decreased platelet counts and lymphocytes.
CONCLUSIONS: Although elevated levels of AST, NLR, PLR, and LMR were found in patients with COVID-19, they were not linked to mortality. Given the presence of AST in other tissues, the influence of SARS-CoV-2 on the liver should be interpreted with caution.