背景:许多研究承认充足的蔬菜消费对人类健康的重要性。然而,由于自我报告和/或细节不足,目前估计蔬菜摄入量的方法通常容易出现测量误差。更客观的蔬菜摄入生物标志物,使用生物标本,是首选。目前可用的唯一浓度生物标志物是血液类胡萝卜素和维生素C,涵盖水果和蔬菜的总摄入量。需要识别特定蔬菜的生物标志物,以便更好地了解它们对人类健康的相对重要性。在联合规划倡议“健康饮食促进健康生活”下的FoodBAll项目中,通过系统回顾现有文献,我们采取了一项雄心勃勃的行动,为欧洲消费的所有主要食品群体确定候选摄入量生物标志物.这项研究描述了关于叶类食物摄入候选生物标志物(BFIs)的综述,灯泡,和茎蔬菜,这是在PubMed中进行的,Scopus和WebofScience的研究发表到2019年3月。
结果:总计,65篇全文被评估为绿叶蔬菜的资格,并筛选了6篇全文为球茎类蔬菜。确定了菠菜的推定BFI,生菜,菊花,芦笋,朝鲜蓟,还有芹菜,但不是火箭沙拉。然而,在通过FoodBAll财团开发的验证方案进行关键评估之后,没有一个推定的生物标志物似乎是有希望的BFI。食品化学数据表明,一些候选BFI可能会通过进一步的研究揭示出来。
结论:未来的随机对照喂养研究结合观察性研究,应用非靶向代谢组学方法,需要确定有价值的BFI来摄入绿叶,灯泡,和茎蔬菜。
BACKGROUND: Numerous studies acknowledged the importance of an adequate vegetable consumption for human health. However, current methods to estimate vegetable intake are often prone to measurement errors due to self-reporting and/or insufficient detail. More objective intake biomarkers for vegetables, using biological specimens, are preferred. The only concentration biomarkers currently available are blood carotenoids and vitamin C, covering total fruit and vegetable intake. Identification of biomarkers for specific vegetables is needed for a better understanding of their relative importance for human health. Within the FoodBAll Project under the Joint Programming Initiative \"A Healthy Diet for a Healthy Life\", an ambitious action was undertaken to identify candidate intake biomarkers for all major food groups consumed in Europe by systematically reviewing the existent literature. This study describes the
review on candidate biomarkers of food intake (BFIs) for leafy, bulb, and stem vegetables, which was conducted within PubMed, Scopus and Web of Science for studies published through March 2019.
RESULTS: In total, 65 full-text articles were assessed for eligibility for leafy vegetables, and 6 full-text articles were screened for bulb and stem vegetables. Putative BFIs were identified for spinach,
lettuce, endive, asparagus, artichoke, and celery, but not for rocket salad. However, after critical evaluation through a validation scheme developed by the FoodBAll consortium, none of the putative biomarkers appeared to be a promising BFI. The food chemistry data indicate that some candidate BFIs may be revealed by further studies.
CONCLUSIONS: Future randomized controlled feeding studies combined with observational studies, applying a non-targeted metabolomics approach, are needed in order to identify valuable BFIs for the intake of leafy, bulb, and stem vegetables.