随着基因工程技术的最新进展,基因治疗现在被认为不仅是先天性疾病的治疗,而且是获得性疾病的治疗,比如癌症。遗传性免疫疾病的基因治疗剂,血友病,视网膜疾病,神经退行性疾病,淋巴瘤已在美国和欧洲获得批准。在皮肤病学领域,已经进行了基因治疗的临床试验,因为皮肤是一个容易接近的器官,代表了基因治疗的一个有吸引力的组织。近年来,基因治疗已被尝试用于各种皮肤病,如遗传性皮肤病(包括大疱性表皮松解症和Netherton综合征),皮肤淋巴瘤,还有恶性黑色素瘤.因此,基因治疗在皮肤科的应用现状难以把握。本文重点介绍了当前使用的每种基因转移技术,并描述了使用每种技术进行皮肤病基因治疗的现状。
With recent advances in genetic engineering technology, gene therapy is now being considered as a treatment not only for congenital diseases but also acquired diseases, such as cancer. Gene therapeutic agents for hereditary immune disorders, haemophilia, retinal diseases, neurodegenerative diseases, and lymphoma have been approved in the United States and Europe. In the field of dermatology, clinical trials of gene therapy have been conducted, because the skin is an easily accessible organ that represents an attractive tissue for gene therapy. In recent years, gene therapy has been attempted for a variety of skin diseases, such as genodermatoses (including epidermolysis bullosa and Netherton syndrome), cutaneous lymphoma, and malignant melanoma. As a result, it is difficult to grasp the current status of gene therapy in dermatology. This
review focuses on each of the gene-transfer techniques currently in use and describes the current status of gene therapy for skin diseases using each technology.