■喉软骨骨髓瘤(MLC)是一种罕见的浆细胞肿瘤,尚未得到很好的表征。然而,它是喉软骨肿块的重要鉴别诊断,因为它可以指示潜在的全身性血液系统疾病的存在,如多发性骨髓瘤(MM),这与预后不良有关。本文是此类文章中的第一篇,旨在教育临床医生对类似病例的未来诊断和管理。
■在Medline的医学文献数据库上搜索MLC,pubmed,和EMBASE。此外,黄金海岸大学医院放射科的机构数据库被查询为相关病例。根据符合纳入标准的16个案例,病因,流行病学,临床评估,调查,管理,并对MLC的预后进行总结。
■所有,94%的MLC发生在男性中,81%发生在60岁以上的人群中。它更常见的是系统性MM的表现,而不是局部的髓外浆细胞瘤(EMP),分别为81%和19%。此外,67%的喉EMPs在初次诊断后3年内进展为MM。尽管包括局部和全身治疗的治疗都能有效缓解局部症状,39%的MLC患者在随访期间死亡-所有这些都是由于继发感染引起的败血症。
喉软骨骨髓瘤是一种相对罕见的疾病,需要准确的诊断,以便及时治疗潜在的潜在全身性血液病。目前,需要更多的病例报告和分析研究来提供病因学的循证指导,诊断,和管理这种情况。
UNASSIGNED: Myeloma of laryngeal cartilage (MLC) is a rare plasma cell neoplasm which has not been well characterized. However, it is an important differential diagnosis of laryngeal cartilage mass as it can indicate the presence of underlying systemic hematological diseases, such as multiple myeloma (MM), that is associated with poor prognosis. This article is the first of its kind and aims to educate clinicians on future diagnosis and management of similar cases.
UNASSIGNED: Search of MLC was performed on the medical literature databases of Medline, PUBMED, and EMBASE. Additionally, institutional database at Gold Coast University Hospital Radiology Department was queried for relevant cases. Based on 16 cases that met the inclusion criteria, the etiology, epidemiology, clinical evaluation, investigations, management, and prognosis of MLC was summarized.
UNASSIGNED: Of all, 94% of MLC occur in males and 81% in those older than 60 years. It is more commonly a manifestation of systemic MM, rather than localized extramedullary plasmacytoma (EMP), 81% and 19% respectively. Additionally, 67% of laryngeal EMPs progress to MM within 3 years from initial diagnosis. Although treatments involving both local and systemic therapy were effective at relieving local symptoms, 39% of MLC patients died during the follow-up period-all of which were due to septicemia caused by secondary infections.
UNASSIGNED: Myeloma of laryngeal cartilage is a relatively rare condition that requires accurate diagnosis in order to promptly manage the potentially underlying systemic hematological disease. Currently, more
case reports and analytical studies are required to provide evidence-based guidance on etiology, diagnosis, and management of this condition.