背景:一项长期随访研究用于分析骨肉瘤(OS)患者KISS1/GPR54蛋白表达与临床预后的关系。
方法:研究了2005年至2009年期间保存的44个石蜡包埋的OS样品。关于性别的信息,年龄,病理类型,手术阶段,并从医疗记录中收集临床结果.
结果:这项研究包括25名男性(56.81%)和19名女性(43.19%),诊断时的中位年龄为18岁(范围,12-74岁)。随访时间97~162(121.36±15.46)个月。总生存率和转移率分别为43.18%和65.91%。对于KISS1,阳性表达患者的远端转移率和死亡率分别为85.00%(17/20)和75.00%(15/20)。阴性表达患者分别为50.00%(12/24)和41.67%(10/24)。就生存时间而言,KISS1阳性和阴性患者分别为55.35±14.29和97.46±13.06个月,分别。P<0.05被认为在上述所有三个方面具有统计学意义。对于GPR54,阳性患者的转移率和死亡率分别为66.67%(24/36)和61.11%(22/36),分别,阴性表达患者占62.50%(5/8)和37.50%(3/8)。GPR54阳性和阴性表达患者的生存时间分别为73.97±11.81和92.75±15.42个月,分别;然而,在这三个方面P>0.05。
结论:OS患者平均随访10.11年后,KISS1蛋白的表达与较高的远端转移和较短的生存期相关。GPR54蛋白单独表达时不影响预后。
BACKGROUND: A long-term follow-up
study was used to analyze the relationship between
KISS1/GPR54 protein expression and the clinical prognosis of osteosarcoma (OS) patients.
METHODS: Forty-four paraffin-embedded OS samples conserved during the period from 2005 to 2009 were studied. Information about gender, age, pathological type, surgical stage, and clinical outcome was collected from the medical records.
RESULTS: This
study included 25 males (56.81%) and 19 females (43.19%) with a median age at diagnosis of 18 years (range, 12-74 years). The follow-up duration ranged from 97 to 162 (121.36±15.46) months. The overall survival and metastatic rates were 43.18% and 65.91% respectively. For
KISS1, the rate of distal metastasis and mortality in positive expression patients were 85.00% (17/20) and 75.00% (15/20) respectively, and 50.00% (12/24) and 41.67% (10/24) in negative expression patients respectively. In terms of survival time,
KISS1 positive and negative patients were 55.35±14.29 and 97.46±13.06 months, respectively. P<0.05 was considered statistically significant in all three of the above aspects. For GPR54, the rate of metastasis and mortality of positive patients were 66.67% (24/36) and 61.11% (22/36), respectively, and 62.50% (5/8) and 37.50% (3/8) in negative expression patients. The survival time of GPR54 positive and negative expression patients were 73.97±11.81 and 92.75±15.42 months, respectively; however, P>0.05 in these three aspects.
CONCLUSIONS: Expression of
KISS1 protein correlated with higher distal metastasis and shorter survival time in OS patients after an average of 10.11 years of follow-up. GPR54 protein did not affect the prognosis when expressed alone.