环境污染已成为人类关注的问题。美国的弗林特水危机指出,重金属污染日益严重,主要由铅,镉,汞和砷。尽管在动植物中没有任何生物学作用,它们在暴露(急性或慢性)后表现出有害作用。即使是低剂量,它们会影响大脑,肾脏和心脏。氧化应激被称为重金属诱导的肾毒性的原因和作用。在治疗策略中,不同的螯合剂,维生素和矿物质都包括在内,虽然螯合剂已显示出不同的致命缺点。有趣的是,植物和植物衍生的化合物已显示出对重金属诱导的肾毒性的可能有效性。这篇综述将提供铅的毒性动力学的详细信息,Cd,汞和砷,治疗策略以及植物衍生化合物保护肾脏的可能有益作用。
Environmental pollution has become a concerning matter to human beings. Flint water crisis in the USA pointed out that pollution by heavy metal is getting worse day by day, predominantly by Lead, Cadmium, Mercury and Arsenic. Despite of not having any biological role in flora and fauna, they exhibit detrimental effect following exposure (acute or chronic). Even at low dose, they affect brain, kidney and heart. Oxidative stress has been termed as cause and effect in heavy metal-induced kidney toxicity. In treatment strategy, different chelating agent, vitamins and minerals are included, though chelating agents has been showed different fatal drawbacks. Interestingly, plants and plants derived compounds had shown possible effectiveness against heavy metals induced kidney toxicity. This
review will provide detail information on toxicodynamics of Pb, Cd, Hg and As, treatment strategy along with the possible beneficiary role of plant derived compound to protect kidney.