目的:研究印度胶原血管疾病患者眼部表现的频率和特征。
方法:回顾性分析73例(男性:女性16:57)年龄在22至78岁之间(平均±SD=43.5±12.9岁)的胶原性血管疾病患者的病历,胶原血管疾病的亚型,以及完整的眼科检查结果。
结果:39例红斑狼疮(LE)(53.4%,(SLE18,DLE21),系统性硬化症27例(37%),5例皮肌炎(6.8%),2例(2.7%)患者的原发性干燥综合征,分别,被观察到。只有35例(47.9%)患者有眼部表现。在LE干燥性角膜结膜炎(n=6)中,角膜炎(n=5),严重的眼睑炎(n=3),视网膜病变(n=2),一名患者的视神经炎,分别,是主要的眼部表现。系统性硬化症中发生的主要异常包括严重程度可变的眼睑活动受限(n=8),眼睑毛细血管扩张症(n=5),干燥性角膜结膜炎(n=6),白内障(n=5),浅孔穴(n=4),结膜表面疾病(n=4),和葡萄膜炎,角膜炎,每个病人都有上巩膜炎,分别。一名患有皮肌炎的患者患有天麻皮疹。两名原发性干燥综合征患者患有干燥性角膜结膜炎。
结论:研究表明,LE常伴有干燥性角膜结膜炎,视网膜病变,和视神经炎.系统性硬化症通常会导致眼睑不动,眼睑炎和毛细血管扩张症,眼表疾病和干燥性角膜结膜炎,角膜异常,还有葡萄膜炎.全面的眼部评估对于早期发现和管理尤其是眼表疾病至关重要。葡萄膜炎,和视网膜病变,以防止潜在的视力威胁并发症。局限性包括回顾性研究设计和少量患者进行分层。
OBJECTIVE: To
study frequency and characteristics of ocular manifestations in Indian patients with collagen vascular disorders.
METHODS: The medical records of 73 patients (Males: Females 16:57) aged between 22 and 78 years (mean ± SD = 43.5 ± 12.9 years) with collagen vascular diseases were analyzed retrospectively for demography, subtypes of collagen vascular disease, and findings of complete ophthalmic examination.
RESULTS: Lupus erythematosus (LE) in 39(53.4%, (SLE 18, DLE 21), systemic sclerosis in 27(37%), dermatomyositis in 5(6.8%), and primary Sjögren\'s syndrome in 2(2.7%) patients, respectively, were observed. Only 35(47.9%) patients had ocular manifestations. In LE keratoconjunctivitis sicca (n = 6), keratitis (n = 5), severe blepharitis (n = 3), retinopathy (n = 2), and optic neuritis in one patient, respectively, were major ocular manifestations. Major abnormalities occurring in systemic sclerosis included restricted eyelid mobility of variable severity (n = 8), eyelid telangiectasia (n = 5), keratoconjunctivitis sicca (n = 6), cataract (n = 5), shallow fornices (n = 4), conjunctival surface disease (n = 4), and uveitis, keratitis, episcleritis in one patient each, respectively. One patient with dermatomyositis had heliotrope rash. Two patients with primary Sjögren\'s syndrome had keratoconjunctivitis sicca.
CONCLUSIONS: The
study shows that LE frequently presented with keratoconjunctivitis sicca, retinopathy, and optic neuritis. Systemic sclerosis commonly develops eyelid immobility, blepharitis and telangiectasia, ocular surface disease and keratoconjunctivitis sicca, corneal abnormalities, and uveitis. A comprehensive ocular evaluation is imperative for early detection and management particularly of ocular surface disease, uveitis, and retinopathy to prevent potential sight-threatening complications. Limitations include retrospective
study design and small number of patients for stratification.