肾小球旁细胞瘤是良性的,分泌肾素的肿瘤。肿瘤来自肾脏的近球器官细胞。因为肿瘤是荷尔蒙活跃的,患者通常患有低钾血症,醛固酮增多症,和高血压。在这里,我们描述了一个19岁亚裔女性的案例,她的表现有点不寻常。一名19岁的亚裔女性出现上肢无力,麻木,还有刺痛.在体检时,唯一值得注意的发现是高血压.广泛的检查显示醛固酮水平和血浆肾素活性升高。腹部CT扫描显示左肾下极有2.2厘米的肿块。通过肾部分切除术切除肿块。在微观评估上,肿瘤有血管样外观,均匀的薄片,圆形至多边形细胞,细胞质清晰至嗜酸性细胞。免疫组化染色显示肿瘤细胞CD117、CD34和CD10阳性,ER阴性,PR,CK7,PAX-8,泛细胞角蛋白,EMA,S100,Melan-A,HMB45、SMA和CAIX。诊断为肾小球旁细胞瘤。此病例凸显了定期体检的重要性,以及对出现异常投诉的患者的高度怀疑。
Juxtaglomerular cell tumor is a benign, renin-secreting neoplasm. The tumor arises from the juxtaglomerular apparatus cells of the kidney. Because the tumor is hormonally active, patients usually suffer from hypokalemia, hyperaldosteronism, and hypertension. Herein, we describe a
case of a 19-year-old Asian female with a somewhat unusual presentation. A 19-year-old Asian female presented with upper extremity weakness, numbness, and tingling. On physical examination, the only notable finding was hypertension. Extensive workup revealed elevated aldosterone level and plasma renin activity. CT scan of the abdomen revealed a 2.2 cm mass in the lower pole of the left kidney. The mass was resected by partial nephrectomy. On microscopic evaluation, the tumor had glomoid appearance with sheets of uniform, round to polygonal cells with clear to eosinophilic cytoplasm. Immunohistochemical stains showed the tumor cells to be positive for CD117, CD34 and CD10 and negative for ER, PR, CK7, PAX-8, pan-cytokeratin, EMA, S100, Melan-A, HMB45, SMA and CAIX. Diagnosis of Juxtaglomerular cell tumor was rendered. This
case highlights the importance of a regular physical exam and a high index of suspicion in patients presenting with unusual complaints.