■自闭症谱系障碍(ASD)影响68名儿童中的1名,其特征是社交互动和沟通受损,以及受限或重复的行为,在其原因和陈述方面差异很大。对于ASD的核心症状没有经过验证的药物治疗。社会,medical,ASD对家庭和照顾者的经济负担是深刻的。我们最近在一项小型临床试验中表明,西兰花芽中的萝卜硫素(SF)可以显着减轻ASD的行为症状。
■在我们完成原始试验的干预阶段(2011-2013年)后,许多护理人员使用非处方膳食SF补充剂,以试图保持与干预期间相似的改善.我们定期跟踪研究参与者在2016年夏季的进展。
■接受SF作为原始研究的一部分的26名受试者中的16名的家庭回应了进一步信息的请求。在这些主题中,6研究后未继续服用SF补充剂。16名受试者中有9名仍在服用SF补充剂,第10名计划服用。我们在这个案例系列中介绍了他们的照顾者的编辑推荐。
■许多父母和照顾者阐述了SF的积极影响,本文报道了干预阶段和随后的3年。这些观察结果可能有助于理解ASD和可能减轻其某些症状的治疗。基于饮食和补充的疗法值得仔细考虑,因为它们可能提供有关ASD的重要临床和生化信息。
UNASSIGNED: Autism spectrum disorder (ASD) affects 1 in 68 children, is characterized by impaired social interaction and communication as well as restricted or repetitive behaviors, and varies widely with respect to its causes and presentations. There are no validated pharmacologic treatments for the core symptoms of ASD. The social, medical, and economic burdens of ASD on families and caregivers are profound. We recently showed in a small clinical trial that sulforaphane (SF) from broccoli sprouts could significantly reduce the behavioral symptoms of ASD.
UNASSIGNED: After we completed the intervention phase of the original trial (2011-2013), many caregivers used over-the-counter dietary SF supplements in order to attempt to maintain improvements similar to those noted during the intervention. We periodically followed the progress of study participants through the summer of 2016.
UNASSIGNED: Families of 16 of the 26 subjects who received SF as part of the original study responded to requests for further information. Of these subjects, 6 did not continue taking SF supplements after the study. Nine of the 16 subjects are still taking an SF supplement and a 10th planned to. We present the edited testimonials of their caregivers in this
case series.
UNASSIGNED: Many parents and caregivers articulated the positive effects of SF, both during the intervention phase and in the ensuing 3 years reported herein. These observations may contribute to understanding ASD and to treatments that may alleviate some of its symptoms. Diet- and supplement-based therapies deserve careful consideration for their potential to provide vital clinical as well as biochemical information about ASD.